South Africa Cooperative Research: Oxidation Mechanisms, Effect of pH and Probing of Possible Metal Ion Catalysis in the Reactions of Organosulfur Compounds

南非合作研究：氧化机制、pH 值的影响以及有机硫化合物反应中可能的金属离子催化作用的探讨

• 批准号: 0422689
• 负责人: Reuben Simoyi
• 金额: --
• 依托单位: Portland State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-15 至 2007-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0422689&HistoricalAwards=false
• 关键词: South; Africa; Cooperative; Research; Oxidation

This award funds a two-year international cooperative research investigation on organosulfur chemistry, with a particular focus on oxidation mechanisms, effect of pH, and metal ion catalysis. The collaboration brings the environmental chemistry expertise of Sreekantha Jonnalagadda, from the University of Durban-Westville, South Africa, on the role of sulfur in water, soil and atmospheric chemistry, together with that of Reuben Simoyi's expertise on sulfur compounds in inorganic and model biological systems. The collaborators will undertake a series of experiments to elucidate these chemical reactions using potentiometry, turbidimetry, stopped flow, and Electron Paramagnetic Resonance, and computer simulation techniques. The project will strengthen US-South African collaborations and would provide international research experience for one graduate student and two undergraduates from the U.S. and for one South African student. The scientific results of the project are likely to be of value because information on the oxidation states of sulfur is frustratingly sparse, in spite of the pivotal role that this element plays in environmental and biological systems; more specifically the environmental chemistry results may help mitigate environmental pollution associated with mining activities in the U.S. and in Africa, while the biological investigations that address the balance between the therapeutic vs. toxic potential of thiols may contribute to our understanding of human health. This award is co-funded by the Office of International Science and Engineering and the Division of Chemistry.

该奖项资助一项为期两年的有机硫化学国际合作研究调查，特别关注氧化机制、pH 的影响和金属离子催化。此次合作汇集了南非德班-韦斯特维尔大学 Sreekantha Jonnalagadda 在水、土壤和大气化学中硫的作用方面的环境化学专业知识，以及 Reuben Simoyi 在无机和模型生物中硫化合物方面的专业知识。系统。合作者将进行一系列实验，利用电位测定法、比浊法、停流法、电子顺磁共振以及计算机模拟技术来阐明这些化学反应。该项目将加强美国与南非的合作，并将为来自美国的一名研究生和两名本科生以及一名南非学生提供国际研究经验。该项目的科学成果可能很有价值，因为尽管硫在环境和生物系统中发挥着关键作用，但有关硫氧化态的信息却少得令人沮丧；更具体地说，环境化学结果可能有助于减轻与美国和非洲采矿活动相关的环境污染，而解决硫醇治疗与毒性潜力之间平衡的生物学研究可能有助于我们了解人类健康。该奖项由国际科学与工程办公室和化学部共同资助。