Chiral Magic-Number Clusters & Non-Covalent Complexes Studied by Electrospray Ionization & Ion Soft Landing

手性幻数簇

• 批准号: 0412782
• 负责人: Robert Cooks
• 金额: $ 79.1万
• 依托单位: Purdue University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-15 至 2008-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0412782&HistoricalAwards=false
• 关键词: Chiral; Magic; Number; Clusters; &amp

Professor R. Graham Cooks of Purdue University is supported by the Analytical and Surface Chemistry Program to use the soft ionization capabilities of electrosonic spray ionization to generate molecular clusters probed by mass spectrometry. Reactions of these clusters will be carried out at atmospheric pressure prior to introduction of the products into a mass analyzer. Clusters and products are 'soft landed' onto surfaces (liquids and solids) after mass selection and detected using infrared laser desorption. The work focuses on the homochiral clusters of the amino acid serine discovered in the PI's laboratory, and on issues of chiral amplification and transfer of chirality to other species through enantioselective chemical reactions. Noncovalent bonding is an important topic in understanding interactions between biologically active molecules, as well as in many other areas including colloid chemistry and sensors. Thus, in addition to providing excellent student education, the PI continues to develop mass spectrometry ultimately for biology and security applications, for example.

普渡大学的R. Graham Cooks教授得到了分析和表面化学计划的支持，以利用电体喷雾电离的软电离能力来产生通过质谱法探测的分子簇。在将产品引入质量分析仪之前，这些簇的反应将在大气压下进行。质量选择后，簇和产品被“软着陆”到表面（液体和固体）上，并使用红外激光解吸检测。 这项工作的重点是在PI实验室发现的氨基酸丝氨酸的同类簇，以及通过对映选择性化学反应向其他物种向其他物种转移的手性放大和转移的问题。非共价键合是理解生物活性分子以及包括胶体化学和传感器在内的许多其他领域之间相互作用的重要主题。 因此，除了提供出色的学生教育外，PI还继续为生物学和安全应用开发质谱法。