Nonlinear dynamics of microcantilevers interacting with nanostructures - applications to biomolecular sensing and nanotribology

微悬臂梁与纳米结构相互作用的非线性动力学 - 在生物分子传感和纳米摩擦学中的应用

• 批准号: 0409660
• 负责人: Arvind Raman
• 金额: --
• 依托单位: Purdue University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0409660&HistoricalAwards=false
• 关键词: Nonlinear; dynamics; microcantilevers; interacting; nanostructures

0409660 - Nonlinear dynamics of microcantilevers interacting with nanostructures - applications to biomolecular sensing and nanotribologyThis project explores computationally, and experimentally novel dynamical phenomena underlying the use of scanning probe microcantilevers as mechanical property sensors at the nanoscale. The proposed research targets two applications of key importance in nanostructural property characterization: (a) the measurement and characterization of friction at the nanoscale, and (b) the measurement of mechanical properties of biological macromolecules. In both cases, investigations will be performed to predict the oscillations of microcantilevers in these nanoscale measurement applications. Overall the project will (1) help develop a fundamantal understanding of the physics of atomic scale friciton betweena sharp asperity and nanostructures of interest, especially in sliding speeds of relevance to nanotribology, MEMS and biomolecular systems, (2) help develop design guidelines to tune intentionally the vibration spectrum of these microcantilevers to enhance their performance as nanomechanical property sensors of important biomolecules such as structural proteins and DNA. Finally, the research objectives are complemented by a solid plan for broader impact including specific plans for broader dissemination of research results, increasing participation of minorites and underrepresented groups in research, involving undergraduates in research, and fostering cross disciplinary collaborations with structural biology and condensed matter physics communities on campus.

0409660-微型抗体与纳米结构相互作用的非线性动力学 - 应用于生物分子传感和纳米毕业生的应用，该项目在计算中探索，并实验新颖的动力学现象，将使用扫描探针探针微生物作为机械性能传感器作为纳米级机械性传感器的使用。拟议的研究针对纳米结构特性表征的两个关键的应用：（a）纳米级摩擦的测量和表征，以及（b）生物大分子的机械性能的测量。在这两种情况下，都将进行研究以预测这些纳米级测量应用中的微型竞争者的振荡。总体而言，该项目将（1）帮助建立对原子量表弗里孔物理学的基本理解，而感兴趣的纳米结构之间，尤其是在与纳米脱水的相关速度，MEM和生物分子系统相关的速度下，（2）有助于开发设计指南，以使他们的纤维纤维质量构成质量机器机，以使其具有重要的弹性，以使其具有重要的纤维机器机器机器化的效果。生物分子，例如结构蛋白和DNA。最后，研究目标得到了一项扎实的计划，对更广泛的影响进行了补充，包括更广泛地传播研究结果的计划，增加了少数人的参与和人为不足的群体参与研究，涉及研究生参与研究，并促进了与结构生物学和凝结物质社区的跨学科合作。