CRC: Towards synthetic biology: the replication of synthetic polymers

CRC：迈向合成生物学：合成聚合物的复制

• 批准号: 0404677
• 负责人: David Lynn
• 金额: --
• 依托单位: Emory University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-06-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0404677&HistoricalAwards=false
• 关键词: CRC; Towards; synthetic; biology; replication

David Lynn, Stefan Lutz and Ichiro Matsumura (Emory University) and Nicholas Hud (Georgia Tech) are jointly supported by the Division of Chemistry to develop self-replicating polymer systems. This interdisciplinary team will pursue both rational and diversity-based approaches to the development ofmacromolecular catalysts for the sequence- and chain length-specific synthesis of chiral polymers. These systems are inspired by the efficiency of DNA and RNA biopolymers in self-assembly and self-replication.Sequence-specific polyesters, polyamines/amides and polyphosphonates will be prepared through the merger of synthetic chemistry, polymer chemistry and directed molecular evolution. This strategy mimics Nature's approach towards the most efficient and most broadly-based routes to such polymers. These robust reactions can be used to select and evolve a synthetic polymer to prepare new functional materials. The implementation of "synthetic biology" or bio-inspired strategies for the production of new chemicals and materials, has been enabled by advances in molecular biology, high throughput screening and sophisticated selection protocols. This project is funded through the Collaborative Research in Chemistry Program (CRC) and provides outstanding opportunities for undergraduates, graduate students, and postdoctoral researchers to acquire knowledge and skills in very broad areas of research, including synthetic organic chemistry, physical organic chemistry, biophysics and structural biology.

David Lynn，Stefan Lutz和Ichiro Matsumura（Emory University）和Nicholas HUD（Georgia Tech）得到了化学部共同支持开发自我复制聚合物系统的支持。这个跨学科的团队将采用基于理性和多样性的方法，用于开发手性聚合物的序列和链长特异性合成的核分子催化剂。这些系统的灵感来自DNA和RNA生物聚合物在自组装和自我复制中的效率。序列特异性聚酯，多胺/酰胺和聚膦酸酯将通过合成化学，聚合物化学和定向分子进化的合并来制备。该策略模仿了自然对此类聚合物最有效，最广泛的途径的方法。这些可靠的反应可用于选择和进化合成聚合物以制备新的功能材料。通过分子生物学，高吞吐量筛选和复杂的选择方案的进步，实现了生产新化学品和材料的“合成生物学”或生物启发的策略。该项目是通过化学研究（CRC）合作研究资助的，并为本科生，研究生和博士后研究人员提供了出色的机会，以在非常广泛的研究领域获得知识和技能，包括合成有机化学，物理有机化学，生物化学，生物物理学和结构生物学。