The Organic Chemistry of Silicon in Small and Large Molecules

小分子和大分子中硅的有机化学

• 批准号: 0349412
• 负责人: Joseph Lambert
• 金额: $ 46.89万
• 依托单位: Northwestern University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0349412&HistoricalAwards=false
• 关键词: Organic; Chemistry; Silicon; Small; Large

With this renewal award the Organic and Macromolecular Chemistry Program continues its support for the work of Professor Joseph B. Lambert of the Department of Chemistry at Northwestern University in Evanston IL. The research will extend the PI's work on the organic chemistry of compounds that contain silicon and other main group elements. Silicon, which is just below carbon in the periodic table, conveys novel properties when replacing carbon. The primary goals of the research are to prepare new molecules with interesting and useful properties. New and unusual organic cations centered on main group elements will be synthesized and their stability evaluated. A series of organosilicon reactions will produce dendrimers of nanodimensions, whose surface is covered with organic hosts that can bind to metal cations and serve as novel catalysts. The ability of fundamental organic molecules of biological interest to react with silicic acid will be investigated with the goal of establishing links between the inorganic and bioorganic worlds with implications in prebiotic chemistry. A diverse, multiracial group that includes students from underrepresented minorities will carry out this research. The research will not only educate those involved in the projects but also undergraduates and the general public though educational activities, books, and lectures. This research is expected to have broad positive impact in the areas of catalysis, industrial separations and purification, environmental remediation, and drug delivery.

通过这一续签奖项，有机和高分子化学项目继续支持伊利诺伊州埃文斯顿西北大学化学系 Joseph B. Lambert 教授的工作。 该研究将扩展 PI 在含有硅和其他主族元素的化合物的有机化学方面的工作。 硅在元素周期表中的位置略低于碳，在取代碳时具有新颖的特性。 该研究的主要目标是制备具有有趣且有用特性的新分子。 将合成以主族元素为中心的新的和不寻常的有机阳离子并评估它们的稳定性。 一系列有机硅反应将产生纳米尺寸的树枝状聚合物，其表面覆盖有有机主体，可以与金属阳离子结合并用作新型催化剂。 将研究具有生物学意义的基本有机分子与硅酸反应的能力，目的是在无机世界和生物有机世界之间建立联系，并对生命起源前的化学产生影响。 包括来自代表性不足的少数族裔的学生在内的多元化、多种族群体将开展这项研究。 该研究不仅将通过教育活动、书籍和讲座对项目参与者进行教育，还会对本科生和公众进行教育。 这项研究预计将在催化、工业分离和纯化、环境修复和药物输送等领域产生广泛的积极影响。