CAREER: Nanothin Films with Selective Pores - Synthesis and Application in Nanobioreactors

职业：具有选择性孔隙的纳米薄膜 - 合成及其在纳米生物反应器中的应用

• 批准号: 0349315
• 负责人: Evgueni Pinkhassik
• 金额: $ 50.67万
• 依托单位: University of Memphis
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0349315&HistoricalAwards=false
• 关键词: CAREER; Nanothin; Films; Selective; Pores

With the support of the Organic Dynamics Program in the Chemistry Division, Professor Pinkhassic, of the Chemistry department at the University of Memphis, will construct thin-film nanocapsules for use as nano-bioreactors in which enzymes will be immobilized. These nano-reactors will be constructed by photochemical polymerization and cross-linking of various olefinic monomers dissolved in the hydrophobic interior of the membrane bilayers of liposomes leading to thin polymer shells. These shells will be released from the membrane by dissolution in detergent solution. By including globular hydrolyzable hydrophobic molecules, the author plans to create pores in the polymer films with the flexibility to line the channels with hydrophobic or hydrophilic interiors. The construction of new porous polymerized lipsome-like materials will open up a range of new possibilities in many areas including biotechnology, separation science, and drug transport.With the support of the Organic Dynamics Program in the Chemistry Division, Professor Pinkhassic will pursue an educational strategy designed to expand the horizons of undergraduate students to the richness of interdisciplinary research. To this end he will develop several interdisciplinary courses at the undergraduate level and involve undergraduates in the interdisciplinary research in his laboratory. Researchers and educators from Rhodes College and Oak Ridge National Laboratory will also be included in these efforts. Outreach to pre-college students in the Memphis area, which is rich in underrepresented minorities, will be accomplished by demonstrations of nanotechnology/supramolecular chemistry.

在孟菲斯大学化学系的化学系有机动力学计划的支持下，将构建薄膜纳米胶囊，以用作将酶固定的酶的纳米纤维反应器。这些纳米反应器将通过光化学聚合和溶解在脂质体的疏水性内部的各种烯烃单体的交联构建，从而构建脂质体的疏水性内部。 这些壳将通过清洁剂溶液中的溶解从膜中释放出来。通过包括可球状水解的疏水分子，作者计划在聚合物膜中创建毛孔，以灵活地将通道与疏水或亲水性室内装饰线。 新的多孔聚合唇孔式材料的建设将在许多领域开放一系列新的可能性，包括生物技术，分离科学和药物运输。在化学部的有机动力学计划的支持下，Pinkhassic教授将寻求一种教育策略，旨在扩大跨学科研究的不足学生的教育策略。 为此，他将在本科层面开发几门跨学科课程，并在其实验室中参与跨学科研究。这些工作也将包括罗德学院和橡树岭国家实验室的研究人员和教育者。 将通过纳米技术/超分子化学的示范来实现孟菲斯地区的大学前学生的宣传，而孟菲斯地区的少数群体不足。