Functional devices made with porous hollow nanocapsules

由多孔中空纳米胶囊制成的功能器件

基本信息

批准号：
1709921
负责人：
Evgueni Pinkhassik
金额：
$ 46.5万
依托单位：
University of Connecticut
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2017
资助国家：
美国
起止时间：
2017-08-01 至 2021-07-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1709921&HistoricalAwards=false
关键词：
Functional devices made porous hollow

项目摘要

With the support of the Macromolecular, Supramolecular, and Nanochemistry Program of the NSF Chemistry Division, the research group of Professor Eugene Pinkhassik at the University of Connecticut creates functional devices based on hollow capsules made of plastic that are no more than 1 billionth of a meter in diameter. These tiny capsules are made of polymers (plastics) and are designed to regulate the uptake and release of bioactive molecules as well as to serve as compartments for containing chemical reactions where the products can be released at will. Such structures are designed to mimic nature. They function in a similar way to cells that control biological functions by housing different enzymes and biological molecules in small specialized compartments. Controlled catch and release functionality of the nanocapsules may lead to new devices for the delivery of drugs and medical imaging agents. A cell-mimicking device capable of producing a product in response to an external stimulus may find biomedical applications, for example, regulating the production of insulin in response to the level of glucose in the management of diabetes. To facilitate technology transfer and to enhance the educational experience, Professor Pinkhassik provides mentoring for graduate and undergraduate students participating in the technology transfer of their research. In the recent years, several graduate students from the research group have won awards in business plan competitions. Many specific sub-goals of this project are application-driven and suitable for students interested in product development and advanced manufacturing.Vesicle-templated polymer nanocapsules are emerging as a viable platform for creating functional devices with superior performance. Controlled polymerization of building blocks in the organized environment of self-assembled bilayers enables the synthesis of nanocapsules with nanometer-thin shells containing nanopores with controlled size and chemical environment. The ease of synthesis coupled with the controlled permeability of the shells and long-term stability of nanocapsules creates an opportunity for building hybrid cell-mimicking nanodevices. With the support of the Macromolecular, Supramolecular, and Nanochemistry Program of the NSF Chemistry Division, this project aims to expand the utility of the nanocapsule platform. Specifically, the Pinkhassik group investigates the reactivity and stability of nanocapsules containing encapsulated enzymes. The researchers seek establish through-shell communication with rotaxane-like structures. Areas of particular interest include enzymatic cascade reactions and externally triggered processes in nanocapsules. The educational and outreach components of this project aim at engaging pre-college students, expanding the participation of underrepresented groups in science, and providing mentorship and research opportunities to students at all levels.

在NSF化学部的大分子，超分子和纳米化学程序的支持下，康涅狄格大学的Eugene Pinkhassik教授的研究小组创建了基于由塑料制成的空心胶囊的功能设备，该塑料制成的空心胶囊不超过超过10亿米的计量米。这些微小的胶囊由聚合物（塑料）制成，旨在调节生物活性分子的摄取和释放，并用作包含可以随意释放产品的化学反应的隔室。这样的结构旨在模仿性质。它们的功能与通过在小型专业隔室中饲养不同酶和生物分子来控制生物学功能的细胞相似。纳米胶囊的受控捕获和释放功能可能会导致新的设备用于输送药物和医学成像剂。能够响应外部刺激的能够生产产物的细胞模拟装置可能会发现生物医学应用，例如，根据糖尿病管理中的葡萄糖水平来调节胰岛素的产生。为了促进技术转移并增强教育经验，Pinkhassik教授为参加他们研究技术转移的研究生和本科生提供指导。近年来，研究小组的几位研究生赢得了商业计划竞赛的奖项。该项目的许多特定子目标都是由应用程序驱动的，适用于对产品开发和先进制造感兴趣的学生。Vesicle-Templypemated的聚合物纳米胶囊正在成为一个可行的平台，用于创建具有出色性能的功能设备。在自组装双层的有组织环境中，构建块的受控聚合使纳米胶囊与纳米胶囊合成纳米壳 - 含有控制尺寸和化学环境的纳米孔。综合的易于性，再加上壳的受控渗透性和纳米胶囊的长期稳定性，为构建杂交细胞模仿纳米电视的构建机会。在NSF化学部的大分子，超分子和纳米化学计划的支持下，该项目旨在扩大纳米胶囊平台的效用。具体而言，Pinkhassik组研究了含有封装酶的纳米胶囊的反应性和稳定性。研究人员寻求通过与轮济烷样结构建立的交流。特别感兴趣的区域包括纳米胶囊中的酶促级联反应和外部触发的过程。该项目的教育和宣传组成部分旨在吸引前大学的学生，扩大代表性不足的小组参与科学的参与，并为各级学生提供指导和研究机会。

项目成果

期刊论文数量（8）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Starting and Sustaining a Laboratory Safety Team (LST)

组建和维持实验室安全团队 (LST)

DOI：
10.1021/acs.chas.0c00016
发表时间：
2020
期刊：
ACS Chemical Health & Safety
影响因子：
3
作者：
Martin, Jessica A.;Miller, Kali A.;Pinkhassik, Eugene
通讯作者：
Pinkhassik, Eugene

Evidence for diffusing atomic oxygen uncovered by separating reactants with a semi-permeable nanocapsule barrier

DOI：
10.1039/c8cc06715e
发表时间：
2019-02-11
期刊：
CHEMICAL COMMUNICATIONS
影响因子：
4.9
作者：
Omlid, Sara M.;Dergunov, Sergey A.;McCulla, Ryan D.
通讯作者：
McCulla, Ryan D.

Controlling the Encapsulation of Charged Molecules in Vesicle-Templated Nanocontainers through Electrostatic Interactions with the Bilayer Scaffold

通过与双层支架的静电相互作用控制囊泡模板纳米容器中带电分子的封装

DOI：
10.1021/acs.langmuir.7b01706
发表时间：
2017
期刊：
Langmuir
影响因子：
3.9
作者：
Kim, Mariya D.;Dergunov, Sergey A.;Pinkhassik, Eugene
通讯作者：
Pinkhassik, Eugene

Unraveling the Single-Nanometer Thickness of Shells of Vesicle-Templated Polymer Nanocapsules

解开囊泡模板聚合物纳米胶囊壳的单纳米厚度

DOI：
10.1021/acs.jpclett.7b01149
发表时间：
2017
期刊：
The Journal of Physical Chemistry Letters
影响因子：
0
作者：
Richter, Andrew G.;Dergunov, Sergey A.;Kim, Mariya D.;Shmakov, Sergey N.;Pingali, Sai Venkatesh;Urban, Volker S.;Liu, Yun;Pinkhassik, Eugene
通讯作者：
Pinkhassik, Eugene

Building Functional Nanodevices with Vesicle-Templated Porous Polymer Nanocapsules