U.S.- U.K. Cooperative Research: Lithiated Heterocycles

美英合作研究：锂杂环化合物

• 批准号: 0328398
• 负责人: Robert Gawley
• 金额: $ 0.28万
• 依托单位: University of Arkansas
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-03-01 至 2004-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0328398&HistoricalAwards=false
• 关键词: U.S.; U.K.; Cooperative; Research; Lithiated

0000096GawleyThis two-year award for U.S.-U.K. collaboration in organic synthetic chemistry involves Robert E. Gawley and a postdoctoral researcher from the University of Miami and Iain Coldham of the University of Exeter. The objective of the collaboration is to develop new methods for the synthesis of complex heterocyclic compounds. The investigators will extend their work on the configurational stability of aminoorganolithiums. Both groups have studied reactivity patterns in these generally unstable compounds and propose to identify structural characteristics using complementary sets of related, yet different compounds. The U.S. investigator brings to this collaboration a unique approach to the study and development of unstabilized alpha-lithio amines. This is complemented by the U.K. investigator's expertise on the structure and preparation of the compounds. His laboratory prepared a compound that demonstrated configurational stability even at room temperature. The project will advance understanding of new methods for synthesizing complex nitrogen heterocycles and of the science of organic synthesis. Heterocyclic compounds are important to pharmacology because the vast majority of pharmaceutical drugs contain the cyclical arrangement of molecules that are typically found in this system.

0000096GAWLEYTHTHIS U.K.有机合成化学合作的两年奖涉及Robert E. Gawley和迈阿密大学的博士后研究员和埃克塞特大学的Iain Coldham。 该协作的目的是开发新方法，以合成复杂的杂环化合物。 研究人员将扩大其在氨基岩的构型稳定性方面的工作。 两组都研究了这些通常不稳定化合物中的反应性模式，并建议使用互补的相关但不同的化合物识别结构特征。 美国研究人员将这一合作带来了一种独特的方法，用于研究和开发未稳定的Alpha-Lithio Amines。 英国研究者在化合物的结构和制备方面的专业知识对此进行了补充。 他的实验室准备了一种化合物，即使在室温下也证明了配置稳定性。 该项目将促进对合成复杂氮杂环和有机合成科学的新方法的理解。 杂环化合物对药理学很重要，因为绝大多数药物都包含该系统中通常发现的分子的周期性排列。