SBIR Phase I: A New Biotherapeutic Approach to Combating Unwanted Bacteria

SBIR 第一阶段：对抗有害细菌的新生物治疗方法

• 批准号: 0319810
• 负责人: Hideki Suzuki
• 金额: $ 9.97万
• 依托单位: CONJUGON
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0319810&HistoricalAwards=false
• 关键词: SBIR; Phase; New; Biotherapeutic; Approach

This Small Business Innovation Research Phase I project will develop a new method for killing unwanted and antibiotic-resistant bacteria. The problem of antibiotic-resistant bacteria is becoming a crisis of epic proportions. Overuse and misuse of antibiotics is seen as a major cause of this problem. In June 2001, the American Medical Association went on record opposing the use of antibiotics in agriculture for "non- therapeutic" use in animals. A Public Health Action Plan, written by a federal task force, recommends that entirely new approaches are needed to go beyond the use of traditional antibiotics to employ novel anti-microbial agents that kill pathogens while minimizing the ability of the target bacteria to develop horizontally transferable resistance. The goal of this project is to develop just such a technology. The proposed technology does not incorporate traditional chemical antibiotics, but utilizes well-understood biological processes in a novel and proprietary fashion. It involves engineering harmless bacteria to kill unwanted bacteria by redundant mechanisms that will minimize the development of resistance. The commercial applications of this project are expected to be primarily in the areas of agriculture and veterinary medicine. Initial project efforts will be aimed at combatting Fire Blight (Erwinia amylovora) in fruit crops and reducing Salmonella contamination in poultry.

这个小型企业创新研究阶段I项目将开发一种杀死不需要和抗生素耐药菌的新方法。抗生素耐药细菌的问题正成为史诗比例的危机。过度使用和滥用抗生素被视为该问题的主要原因。 2001年6月，美国医学协会（American Association）记录了反对在农业中使用抗生素在动物中使用“非治疗性”用途的。联邦工作队制定的公共卫生行动计划建议，需要采用全新的方法来超越传统的抗生素采用新颖的抗微生物剂，以杀死病原体，同时最大程度地减少目标细菌发展水平转移抗性的能力。该项目的目的是开发这样的技术。提出的技术不融合传统的化学抗生素，而是以新颖和专有的方式利用了良好的生物学过程。它涉及工程无害的细菌，以通过冗余机制杀死不需要的细菌，从而最大程度地减少抗药性的发展。 该项目的商业应用预计将主要在农业和兽医医学领域。最初的项目努力将旨在打击水果作物中的消防疫苗（Erwinia amylovora），并减少家禽中的沙门氏菌污染。