NIRT: Rationally Designed Nanosensing Substrates for Chemical and Biodetection

NIRT：合理设计的用于化学和生物检测的纳米传感基质

• 批准号: 0304097
• 负责人: Naomi Halas
• 金额: --
• 依托单位: William Marsh Rice University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-15 至 2008-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0304097&HistoricalAwards=false
• 关键词: NIRT; Rationally; Designed; Nanosensing; Substrates

EEC-0304097William Marsh Rice UniversityHalasThe objective of this 48-month project is to investigate surface enhanced spectroscopy as a sensing tool for the nanostructure-enhanced chemical and biological detection, with a focus on minimal sample preparation and sample contact. The research goals include: (1) to design, construct and optimize nanostructure-based substrates for ultra sensitive detection of molecules based on Surface Plasmon Resonance Spectroscopy, Surface Enhanced Raman Spectroscopy, Fluorescence Spectroscopy, and Surface Enhanced Infrared Spectroscopy; (2) to develop a comprehensive fundamental understanding of nanostructure-enhanced chemical detection by accurately modeling the substrate, the molecule and the near field at the substrate-molecule interface., and (3) to apply this fundamental understanding to the chemical detection of small molecules, functional groups characteristic of chemical, biological and explosive agents, to proteins and ultimately to micron-sized protein-coated objects.

EEC-0304097William Marsh Rice UniversityHalas 这个为期 48 个月的项目的目标是研究表面增强光谱作为纳米结构增强化学和生物检测的传感工具，重点是尽量减少样品制备和样品接触。 研究目标包括：（1）设计、构建和优化基于纳米结构的基底，用于基于表面等离子共振光谱、表面增强拉曼光谱、荧光光谱和表面增强红外光谱的分子超灵敏检测； (2) 通过对基底、分子和基底-分子界面的近场进行精确建模，形成对纳米结构增强化学检测的全面基本理解。(3) 将这一基本理解应用于小分子的化学检测。分子、化学、生物和爆炸剂特有的官能团，到蛋白质，并最终到微米大小的蛋白质涂层物体。