NIRT: Rationally Designed Nanosensing Substrates for Chemical and Biodetection

NIRT：合理设计的用于化学和生物检测的纳米传感基质

• 批准号: 0304097
• 负责人: Naomi Halas
• 金额: --
• 依托单位: William Marsh Rice University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-15 至 2008-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0304097&HistoricalAwards=false
• 关键词: NIRT; Rationally; Designed; Nanosensing; Substrates

EEC-0304097William Marsh Rice UniversityHalasThe objective of this 48-month project is to investigate surface enhanced spectroscopy as a sensing tool for the nanostructure-enhanced chemical and biological detection, with a focus on minimal sample preparation and sample contact. The research goals include: (1) to design, construct and optimize nanostructure-based substrates for ultra sensitive detection of molecules based on Surface Plasmon Resonance Spectroscopy, Surface Enhanced Raman Spectroscopy, Fluorescence Spectroscopy, and Surface Enhanced Infrared Spectroscopy; (2) to develop a comprehensive fundamental understanding of nanostructure-enhanced chemical detection by accurately modeling the substrate, the molecule and the near field at the substrate-molecule interface., and (3) to apply this fundamental understanding to the chemical detection of small molecules, functional groups characteristic of chemical, biological and explosive agents, to proteins and ultimately to micron-sized protein-coated objects.

EEC-0304097William Marsh Rice Universityhalas这个48个月项目的目标是研究表面增强的光谱学作为纳米结构增强化学和生物学检测的感应工具，重点是最小的样品制备和样品接触。 研究目标包括：（1）基于表面等离子体共振光谱，表面增强的拉曼光谱学，荧光光谱和表面增强的红外光谱法，设计，构建和优化基于纳米结构的底物，以对分子进行超敏感性检测； （2）通过准确对底物，分子和基板 - 分子界面上的分子和近场建模来发展对纳米结构增强化学检测的全面理解。分子，化学，生物学和爆炸性剂的官能团，最终属于微米大小的蛋白质涂层物体。