CAREER: Theoretical Investigations of Non-Equlibrium Processes in Chemistry and Biology

职业：化学和生物学中非平衡过程的理论研究

• 批准号: 0237105
• 负责人: Anatoly Kolomeisky
• 金额: $ 46.5万
• 依托单位: William Marsh Rice University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0237105&HistoricalAwards=false
• 关键词: CAREER; Theoretical; Investigations; Non; Equlibrium

Anatoly Kolomeisky of Rice University is supported by the Theoretical and Computational Chemistry Program to pursue research and disseminate knowledge in the area of non-equilibrium processes relevant to a microscopic chemistry-based understanding of biology. He will study the dynamics of polymer translocation across nanopores, extend models to explain why the ligand-receptor bond rupture as a function of loading rate deviates from Hooke's law, investigate molecular motors, and determine the mechanisms for polymerization in biologically interesting filaments. This field lies at the interface of chemistry, physics and biology and the research will be closely coupled to the training of undergraduate, graduate and postdoctoral students.The underlying role of physical chemistry in biology remains an intellectually challenging problem area of great relevance to future biochemical technologies. Problems addressed in this proposal will allow for a better understanding of targeted delivery of pharmaceuticals and subsequent dispersal. A related area in need of a microscopic understanding is how conversion of energy into motion proceeds in biological systems. Examples of such processes, all of which are facilitated by molecular motors, include cell division and transport, molecular contraction and genetic transcription. Kolomeisky plans to extend his research on molecular motors. Imparting the knowledge and requisite skills to a multidisciplinary array of chemical, biological and physical scientists will be accomplished by introducing a course on biophysical chemistry that is aimed at the advanced undergraduate or beginning graduate level student. Early interest in this new area will be raised by outreach to high school students and teachers.

赖斯大学的Anatoly Kolomeisky得到了理论和计算化学计划的支持，旨在在与基于微观化学的生物学理解有关的非平衡过程领域进行研究和传播知识。 他将研究跨纳米孔的聚合物易位的动力学，扩展模型，以解释为什么配体 - 受体键破裂与加载速率的函数相对于胡克定律偏离，研究分子电机，并确定生物学有趣的细丝中聚合的机制。 该领域位于化学，物理和生物学的界面，研究将与本科，研究生和博士后生的培训紧密相结合。物理化学在生物学中的潜在作用仍然是与未来生物化学化学化学物质相关的智力挑战性问题领域技术。 本提案中解决的问题将使对药品的有针对性交付和随后的分散有更好的了解。 需要微观理解的相关领域是能量转化为生物系统中运动的转化。这些过程的示例，所有这些过程均由分子电动机促进，包括细胞分裂和运输，分子收缩和遗传转录。 Kolomeisky计划扩展他对分子电机的研究。 通过引入针对高级本科生或初学者研究生级的学生，将实现一系列化学，生物学和物理科学家的知识和必要技能，将实现一系列的化学，生物和物理科学家。 与高中生和老师的宣传将提高对这个新领域的早期兴趣。