Silica-Based Hybrid Media for Chromatographic Applications

用于色谱应用的二氧化硅基混合介质

• 批准号: 0138114
• 负责人: Luis Colon
• 金额: $ 41.3万
• 依托单位: SUNY at Buffalo
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-01 至 2005-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0138114&HistoricalAwards=false
• 关键词: Silica; Based; Hybrid; Media; Chromatographic

This award to Professor Luis Colon of the SUNY at Buffalo is supported by the Analytical and Surface Chemistry Program in the Chemistry Division. The proposed investigations are focused on the synthesis and characterization of silica-based organic-inorganic hybrid materials for use in high performance liquid chromatography (HPLC) and capillary electrochromatography (CEC). The silica hybrids will be synthesized by copolymerizing alkoxysilanes with hydrolyzable alkoxide groups. This approach results in the production of chromatographic materials in different formats (i.e., films, monoliths, and particles), some with the potential for stability over a wide pH range. The solution chemistry will be monitored with NMR; the physicochemical characteristics of the organic-inorganic hybrids will be assessed using ESCA, SIMS, FTIR, SEM and/or TEM, microbalance gravimetric analysis, and nitrogen gas adsorption methods. The proposed investigations are directed toward the synthesis and characterization of silica glasses. Different formats of the material will be synthesized, suitable for chemical separations. The different parameters used during the fabrication process will be studied to establish the reaction conditions leading to materials with the best performance. The characteristics and compositions of the synthesized glasses will be assessed using a variety of spectroscopic and physical probes. Fabricated materials such as these have potential applications to the separation and purification of a large number of chemicals, ranging from pharmaceutical to environmental areas. These investigations are part of a long-term research program focused on the development and study of new and improved materials for chemical separations in the liquid phase. The research program mainly involves graduate and undergraduate in executing the experimentation, contributing to the education, development, and training of a new generation of scientists.

该奖项授予布法罗纽约州立大学的路易斯·科隆教授，得到了化学部的分析和表面化学计划的支持。该提出的研究集中在基于二氧化硅的有机无机杂交材料的合成和表征上，用于高性能液相色谱（HPLC）和毛细血管电纹义（CEC）。 二氧化硅杂种将通过与可水解烷氧化物基团共聚的烷氧基硅烷合成。这种方法会以不同格式（即膜，巨石和颗粒）生产色谱材料，其中一些具有在较宽的pH范围内稳定性的潜力。溶液化学将用NMR监测；将使用ESCA，SIMS，FTIR，SEM和/或TEM，微量平衡重量分析以及氮气吸附方法评估有机无机杂交的物理化学特征。 提出的研究针对二氧化硅玻璃的合成和表征。将合成不同格式的材料，适用于化学分离。 将研究在制造过程中使用的不同参数，以确定导致具有最佳性能的材料的反应条件。 合成眼镜的特征和组成将使用多种光谱和物理探针进行评估。诸如此类的制造材料具有潜在的应用，可用于分离和纯化大量化学物质，范围从药物到环境区域。这些研究是一项长期研究计划的一部分，该研究旨在开发和研究液相化学分离的新材料和改进的材料。 该研究计划主要涉及毕业和本科生执行实验，为新一代科学家的教育，发展和培训做出贡献。