2001 Technology for a Sustainable Environment: High Activity Catalysts for Carbon-Carbon Bond Formation in Water Based on Bulky Water-Soluble Alkylphosphines (TSE01-A)

2001 可持续环境技术：基于大体积水溶性烷基膦的水中碳-碳键形成高活性催化剂（TSE01-A）

• 批准号: 0124255
• 负责人: Kevin Shaughnessy
• 金额: $ 33.6万
• 依托单位: University of Alabama Tuscaloosa
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-01-15 至 2004-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0124255&HistoricalAwards=false
• 关键词: 2001; Technology; Sustainable; Environment; Activity

The focus of this research is the development of highly reactive catalysts for synthetically useful reactions such as the Heck, Suzuki and Buchwald-Hartwig couplings. To this end, water-soluble alkylphosphines will be synthesized and used in conjunction with aqueous-phase palladium-catalyzed coupling reactions. These reactions efficiently provide structures of interest in areas ranging from pharmaceuticals and agricultural chemicals to electronic materials and commodity chemicals.With this new NSF/EPA Technology for a Sustainable Environment (TSE) award, the Organic and Macromolecular Chemistry Program and the Office of Multidisciplinary Activities of the Directorate of Mathematics and Physical Sciences are supporting the research efforts of Dr. Kevin H. Shaughnessy of the Department of Chemistry at the University of Alabama, Tuscaloosa. Professor Shaughnessy will focus his research on developing methodology for the use of a new class of sterically demanding, water-soluble alkylphosphines in palladium-catalyzed C-C and C-heteroatom bond forming reactions using environmentally benign aqueous solvent. Adoption of this methodology by industry could result in the decrease of hazardous waste generation, decrease in energy consumption and decrease in the use of volatile organic solvents. The undergraduate, graduate and post-doctoral students working on this project will gain a fundamental education in organic and organometallic chemistry and approaches to developing environmentally benign chemical reactions.

这项研究的重点是开发用于合成有用反应的高反应性催化剂，例如 Heck、Suzuki 和 Buchwald-Hartwig 偶联。为此，将合成水溶性烷基膦并与水相钯催化偶联反应结合使用。 这些反应有效地提供了从药物和农用化学品到电子材料和商品化学品等领域的感兴趣结构。凭借这项新的 NSF/EPA 可持续环境技术 (TSE) 奖，有机和高分子化学计划以及多学科活动办公室数学和物理科学理事会正在支持阿拉巴马大学塔斯卡卢萨分校化学系 Kevin H. Shaughnessy 博士的研究工作。 Shaughnessy 教授的研究重点是开发在钯催化的 C-C 和 C-杂原子键形成反应中使用新型空间要求高的水溶性烷基膦的方法，该反应使用环境友好的水性溶剂。工业界采用这种方法可以减少危险废物的产生、能源消耗和挥发性有机溶剂的使用。 从事该项目的本科生、研究生和博士后将获得有机和有机金属化学的基础教育以及开发环境友好的化学反应的方法。