NSF-EC Activity: Integration of New Hybrid Materials Containing Biomolecules for the Fabrication of Optical Sensor Systems

NSF-EC 活动：集成含有生物分子的新型混合材料以制造光学传感器系统

• 批准号: 0099862
• 负责人: Nasser Peyghambarian
• 金额: $ 126万
• 依托单位: University of Arizona
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0099862&HistoricalAwards=false
• 关键词: NSF; EC; Activity; Integration; New

This proposal is an interdisciplinary, collaborative, and international program between the University of Arizona Optical Sciences Center (OSC), the Department of Materials Science and Engineering at UCLA, and European-Union researchers. The program is directed at creating and developing the materials, the fabrication processes, and the components needed to demonstrate an integrated, optoelectronic system-on-a-chip capable of multifunctional sensing of chemical and biological agents. The UCLA research involves the development of sol-gel glasses doped with biomolecules that can be used as opto-chemical transducers that exploit the sensitivity and selectivity of antibodies and enzymes. The chemical and biochemical changes of the encapsulated biomolecules can be monitored by optical methods. The research will encompass the development of light sources, photodetectors, and micro-optical systems based on hybrid organic/inorganic materials. The students will receive more than simply "exposure" because they will gain hands-on experience in areas of materials synthesis, processing, spectroscopy, device fabrication and operation, as well as system integration. The interdisciplinary nature of this collaboration will also provide the students with a fundamental understanding of synthesis-property relationships for hybrid optical materials and their applications in chemical and biological sensing.This proposal is an interdisciplinary, collaborative and international program directed at creating and developing the materials, the fabrication processes, and the components needed to demonstrate an integrated, optoelectronic system-on-a-chip capable of sensing chemical and biological agents. The program consists of two components: (1) research and development of chemical and biomedical sensing materials based on the sol-gel encapsulation of biomolecules and (2) research and development of optical sensing techniques that capitalize on the optical properties of the sensing materials. The program will provide strong educational benefits to participating undergraduate and graduate student researchers and make them competitive in the world economy. The breadth of the research and our proposed international training program will ensure that the students will not only become experts in their own field of specialization, but that they also will achieve a detailed understanding of the entire sensor system. The students' knowledge will encompass the fundamental chemical and physical science and engineering of the transducer and optical system, and the realities of device fabrication. This project is being co-funded by the Mathematical and Physical Sciences Directorate (Office of Multidisciplinary Affairs, Division of Materials Research, Chemistry Division) and the Engineering Directorate (Chemical and Transport Systems Division).

该建议是亚利桑那大学光学科学中心（OSC），UCLA材料科学与工程系和欧洲联合国研究人员之间的跨学科，合作和国际计划。该程序旨在创建和开发材料，制造过程以及演示能够多功能化学和生物学剂多功能感测的集成的光电系统系统。 UCLA研究涉及掺有生物分子的溶胶 - 凝胶玻璃，可以用作光化化学传感器，从而利用抗体和酶的敏感性和选择性。可以通过光学方法监测包裹的生物分子的化学和生化变化。该研究将涵盖基于混合有机/无机材料的光源，光电探测器和微光学系统的开发。这些学生将不仅会获得“暴露”，因为他们将在材料合成，加工，光谱，设备制造和操作以及系统集成方面获得动手经验。这项合作的跨学科性质还将为学生提供对合成的综合性关系的基本理解，用于混合光学材料及其在化学和生物学感应中的应用。该建议是一项跨学科，协作和国际计划，旨在创建和开发材料的材料，构造的组成过程，以及对整合的组成的组合，以及对材料的组成部分，并具有综合性的组合，并具有相结合的组合 - 系统 - 系统 - 构造的组合 - 系统 - 系统 - 系统 - 系统 - 系统 - 系统 - 系统 - 系统 - 系统 - 系统 - 系统 - 系统 - 系统 - 系统 - 系统 - 系统 - 系统 - 系统 - 系统 - 系统 - 系统 - 系统 - 系统 - 系统 - 系统 - 系统 - 系统 - 系统 - 系统 - 系统 - 系统 - 系统 - 系统 - 系统 - 系统 - 系统 - 系统 - 系统 - 系统 - 系统 - 系统 - 系统 - 系统 - 系统 - 系统 - 构造的组合 - 良好的系统 - 构成的组合 - 代理商。该程序由两个组成部分组成：（1）基于生物分子的溶胶 - 凝胶封装的化学和生物医学传感材料的研究和开发，以及（2）研究和开发光学传感技术，这些技术利用了感应材料的光学性质。该计划将为参与的本科生和研究生研究人员提供强大的教育利益，并使他们在世界经济中竞争。研究的广度和我们提出的国际培训计划将确保学生不仅成为自己专业领域的专家，而且还将对整个传感器系统进行详细的了解。学生的知识将涵盖传感器和光学系统的基本化学和物理科学以及工程以及设备制造的现实。该项目由数学和物理科学局（化学和交通系统部）和工程局（化学和运输系统部）共同资助。