PECASE: Analysis of Novel Composite Tissue Engineered Systems

PECASE：新型复合组织工程系统的分析

• 批准号: 0093805
• 负责人: Karen Burg
• 金额: $ 37.5万
• 依托单位: Clemson University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2006-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0093805&HistoricalAwards=false
• 关键词: PECASE; Analysis; Novel; Composite; Tissue

0093805Karen BurgResearch and development of engineered tissue has potential widespread medical application, including lumpectomy reconstruction, liver repair, cartilage replacement, or other conditions. Tissue engineering involves taking a small number of healthy cells from a patient, growing the cells into large numbers in a laboratory environment, combining them with an absorbable (similar to biodegradable) material that has been sculpted into the anatomical shape of the injured part, allowing the cells to develop, implanting the cell-material system into the patient, and then allowing the cells to grow and acquire the original anatomical shape. The material gradually breaks down, is "absorbed" by the body, and is thus removed.The proposed 5-year work is a focus on the basic science of breast tissue engineering for cancer patients who have undergone a mastectomy or lumpectomy. The effort will be to develop a program in tissue engineering, encompassing the research and development of new injectable materials and training of graduate and undergraduate students. It also will promote public awareness of bioengineering and critical thinking through the development of a K-12 educational outreach program, a program developed through the combined efforts of the Department of Bioengineering and the Department of Education at Clemson University. The mission of the proposed research is to present and justify a new materials approach to tissue engineering. It is hypothesized that by providing a two-phase, composite, injectable material, cell growth and tissue development may be enhanced within a clinically viable solution. Previous studies by the applicant have demonstrated general efficacy of such systems, but have not encompassed a careful assessment of the components. A selection of crafted materials of varying proportions will be addressed and the research will be conducted using a comprehensive battery of mechanical and chemical tests to assess the systems. The success of the basic research concept relies on a well-orchestrated research plan, as well as on education of the involved scientists and future scientists. The science and technology derived from this work will be transferred to other clinical applications presenting similar requirements.

0093805KAREN BURGRESEARCH和工程组织的开发具有潜在的广泛医疗应用，包括重建，肝脏修复，软骨更换或其他疾病。 组织工程涉及从患者中吸收少量健康细胞，在实验室环境中将细胞大量生长成大量，将它们与可吸收（类似于可生物降解的）材料结合在一起，该材料已被雕刻成受伤部件的解剖学形状，使细胞可以发展为患者，然后将细胞系统植入患者，然后将细胞植入并获得原始的塑料，从而使细胞植入并获得原始的形成。 该材料逐渐分解，被人体“吸收”，因此被去除。拟议的5年工作是针对接受乳腺切除术或乳房切除术的癌症患者的乳腺组织工程基础科学的重点。 努力是制定组织工程方面的计划，涵盖新型材料的研究和开发以及研究生和本科生的培训。 它还将通过开发K-12教育外展计划来提高公众对生物工程和批判性思维的认识，这是通过生物工程系和克莱姆森大学教育系的共同努力制定的计划。 拟议的研究的使命是提出和证明一种新的材料方法来进行组织工程。 假设，通过提供两相，复合材料，可注射材料，在临床上可行的溶液中可以增强细胞生长和组织发育。 申请人先前的研究证明了此类系统的一般功效，但尚未仔细评估组件。 将解决各种比例的精选材料，并将使用全面的机械和化学测试来进行研究来评估系统。 基础研究概念的成功依赖于精心策划的研究计划，以及所涉及的科学家和未来科学家的教育。 从这项工作中得出的科学和技术将转移到提供类似要求的其他临床应用中。