U.S.- U.K. Cooperative Research: Lithiated Heterocycles

美英合作研究：锂杂环化合物

• 批准号: 0000096
• 负责人: Robert Gawley
• 金额: $ 2.28万
• 依托单位: University of Miami
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-01 至 2003-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0000096&HistoricalAwards=false
• 关键词: U.S.; U.K.; Cooperative; Research; Lithiated

0000096GawleyThis two-year award for U.S.-U.K. collaboration in organic synthetic chemistry involves Robert E. Gawley and a postdoctoral researcher from the University of Miami and Iain Coldham of the University of Exeter. The objective of the collaboration is to develop new methods for the synthesis of complex heterocyclic compounds. The investigators will extend their work on the configurational stability of aminoorganolithiums. Both groups have studied reactivity patterns in these generally unstable compounds and propose to identify structural characteristics using complementary sets of related, yet different compounds. The U.S. investigator brings to this collaboration a unique approach to the study and development of unstabilized alpha-lithio amines. This is complemented by the U.K. investigator's expertise on the structure and preparation of the compounds. His laboratory prepared a compound that demonstrated configurational stability even at room temperature. The project will advance understanding of new methods for synthesizing complex nitrogen heterocycles and of the science of organic synthesis. Heterocyclic compounds are important to pharmacology because the vast majority of pharmaceutical drugs contain the cyclical arrangement of molecules that are typically found in this system.

0000096Gawley 这项为期两年的美英有机合成化学合作奖涉及罗伯特·E·高利 (Robert E. Gawley) 以及迈阿密大学的博士后研究员和埃克塞特大学的伊恩·科尔德姆 (Iain Coldham)。 此次合作的目的是开发合成复杂杂环化合物的新方法。 研究人员将扩展他们对氨基有机锂构型稳定性的研究。 两个小组都研究了这些通常不稳定的化合物的反应模式，并提出使用相关但不同的化合物的互补组来识别结构特征。 美国研究人员为此次合作带来了一种独特的方法来研究和开发不稳定的α-锂硫胺。 英国研究人员在化合物结构和制备方面的专业知识对此进行了补充。 他的实验室制备了一种即使在室温下也能表现出构型稳定性的化合物。 该项目将增进对合成复杂氮杂环的新方法和有机合成科学的理解。 杂环化合物对于药理学很重要，因为绝大多数药物都含有该系统中常见的分子的环状排列。