CAREER: Physiological Responses and Anatomical Pathways Involved in the Generation of an Immune Response

职业：参与免疫反应产生的生理反应和解剖途径

• 批准号: 9983624
• 负责人: John Griffin
• 金额: $ 32.67万
• 依托单位: College of William and Mary
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-15 至 2006-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9983624&HistoricalAwards=false
• 关键词: CAREER; Physiological; Responses; Anatomical; Pathways

Griffin9983624CAREER: Physiological Responses and Anatomical Pathways Involved in the Generation of an Immune Response Recent research has shown that during a fever, increased activity can be identified in one area of the brain, the hypothalamus, which is involved in the regulation of body temperature. It has been hypothesized that neurons in this region and their specific connections within the brain are important in the ability to produce a fever in response to an infection. The goal of this research project is to characterize the inherent activity of these neurons and their responses to the chemical messenger prostaglandin E2, which is produced by the brain during an infection and may trigger fevers. Thin slices of brain tissue from the hypothalamus of laboratory rats will be tested in a small temperature chamber. Neurons will also be color stained to show their connections and identify specific chemical messengers. In addition, this project will involve students in all research efforts and bring neuroscience research into the classroom through the use of new forms of education technology. This project will result in the development of an integrated research and educational program, allowing students to conduct investigations in the field of neurobiology. Specific projects will focus on the ability of the brain to control body temperature during normal conditions and in response to an infection, when temperature rises in a response known as a fever. While the production of a fever is a natural defense mechanism designed to enhance the ability to fight infection, extreme elevations in temperature can cause permanent damage to internal organs and even death. With the advent of modern clinical medicine, it is important to understand the mechanisms involved in the production of a fever, so that this response can be controlled, resulting in enhanced benefits and limited risk.

Griffin9983624职业：参与免疫反应产生的生理反应和解剖途径最近的研究表明，发烧期间，可以发现大脑的一个区域——下丘脑——参与体温调节的区域活动增加。据推测，该区域的神经元及其在大脑内的特定连接对于响应感染而产生发烧的能力非常重要。该研究项目的目标是表征这些神经元的固有活动及其对化学信使前列腺素 E2 的反应，前列腺素 E2 是大脑在感染期间产生的，可能会引发发烧。实验室大鼠下丘脑的脑组织薄片将在小型温度室中进行测试。神经元也将被染色以显示它们的连接并识别特定的化学信使。此外，该项目将让学生参与所有研究工作，并通过使用新形式的教育技术将神经科学研究带入课堂。该项目将开发一个综合研究和教育计划，使学生能够在神经生物学领域进行研究。具体项目将重点关注大脑在正常情况下和感染时控制体温的能力，即当体温因发烧而升高时。虽然发烧是一种自然防御机制，旨在增强抵抗感染的能力，但温度极端升高可能会导致内脏器官永久性损伤，甚至死亡。随着现代临床医学的出现，了解发烧产生的机制非常重要，这样才能控制这种反应，从而提高效益并降低风险。