NANOSCALE: Engineered Alpha Helices for Pore Transport Regulation

NANOSCALE：用于孔传输调节的工程阿尔法螺旋

• 批准号: 9986538
• 负责人: Peter Kilpatrick
• 金额: $ 10万
• 依托单位: North Carolina State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-03-01 至 2002-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9986538&HistoricalAwards=false
• 关键词: NANOSCALE; Engineered; Alpha; Helices; Pore

AbstractProposal number: BES-9986538Proposal type: Response to NSF 99-109, Exploratory Research on Biosystems at the NanoscalePrincipal investigator: Peter K. KilpatrickAffiliation: North Carolina State UniversityNANOSCALE: Engineered Alpha Helices for Pore-Transport RegulationThis exploratory project investigates the fabrication and efficacy of nanostructured block-copolymer membranes containing helical polymers. The objective is to mimic biological systems in order to achieve high transport selectivity for biological solutes.Various polymeric microstuctures that form helices with varying degrees of hydrophobicity will be synthesized and assembled in planar phospholipid monolayers and in vesicular membranes. The ability of the various structures will be probed to determine their ability to control solute transport through the membranes according the hydrophobicity of the helix periphery and the resulting pore sizes. Transport measurements are being done with radioactive and fluorescent solutes.

摘要提案编号：BES-9986538提案类型：响应 NSF 99-109，纳米尺度生物系统探索性研究首席研究员：Peter K. Kilpatrick 隶属关系：北卡罗来纳州立大学NANOSCALE：用于孔隙运输调节的工程阿尔法螺旋该探索性项目研究了纳米级生物系统的制造和功效含有螺旋聚合物的纳米结构嵌段共聚物膜。 目的是模拟生物系统，以实现生物溶质的高运输选择性。将合成形成具有不同疏水性程度的螺旋的各种聚合物微结构，并将其组装在平面磷脂单层和囊泡膜中。 将探测各种结构的能力，以确定它们根据螺旋外围的疏水性和所得孔径来控制溶质通过膜运输的能力。 传输测量是用放射性和荧光溶质进行的。