NANOSCALE: Engineered Alpha Helices for Pore Transport Regulation

NANOSCALE：用于孔传输调节的工程阿尔法螺旋

• 批准号: 9986538
• 负责人: Peter Kilpatrick
• 金额: $ 10万
• 依托单位: North Carolina State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-03-01 至 2002-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9986538&HistoricalAwards=false
• 关键词: NANOSCALE; Engineered; Alpha; Helices; Pore

AbstractProposal number: BES-9986538Proposal type: Response to NSF 99-109, Exploratory Research on Biosystems at the NanoscalePrincipal investigator: Peter K. KilpatrickAffiliation: North Carolina State UniversityNANOSCALE: Engineered Alpha Helices for Pore-Transport RegulationThis exploratory project investigates the fabrication and efficacy of nanostructured block-copolymer membranes containing helical polymers. The objective is to mimic biological systems in order to achieve high transport selectivity for biological solutes.Various polymeric microstuctures that form helices with varying degrees of hydrophobicity will be synthesized and assembled in planar phospholipid monolayers and in vesicular membranes. The ability of the various structures will be probed to determine their ability to control solute transport through the membranes according the hydrophobicity of the helix periphery and the resulting pore sizes. Transport measurements are being done with radioactive and fluorescent solutes.

AbstractProposal number: BES-9986538Proposal type: Response to NSF 99-109, Exploratory Research on Biosystems at the NanoscalePrincipal investigator: Peter K. KilpatrickAffiliation: North Carolina State UniversityNANOSCALE: Engineered Alpha Helices for Pore-Transport RegulationThis exploratory project investigates the fabrication and efficacy of nanostructured含有螺旋聚合物的块聚合物膜。 目的是模仿生物系统以实现生物学溶质的高运输选择性。将在平面磷脂单层和囊泡膜中综合并组装形成不同程度疏水性的螺旋形成螺旋的多样性微填形。 将探测各种结构的能力，以确定其根据螺旋外围的疏水性和所得孔径的疏水性控制溶质传输的能力。 通过放射性和荧光溶质进行运输测量。