Gordon Research Conference on Macromolecular Organization and Cell Function to be held on August 6-11, 2000 at Queen

戈登大分子组织和细胞功能研究会议将于2000年8月6日至11日在女王大学举行

• 批准号: 9985952
• 负责人: Natalie Cohen
• 金额: $ 13万
• 依托单位: Gordon Research Conferences
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-06-01 至 2001-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9985952&HistoricalAwards=false
• 关键词: Gordon; Research; Conference; Macromolecular; Organization

The Gordon Research conference on Macromolecular Organization and CellFunction has met since 1987; this will be the eighth conference in this series. The most recent one met at Queens College, Oxford University, U.K. in September, 1998. This proposal requests partial funding for the next conference, to be held again in Oxford, August 6-11, 2000. This conference focuses on the intracellular organization of cellularcomponents, the principles and mechanisms underlying that organization, and the essential role of such organization in cell function and its regulation. The first conferences concentrated on the role of enzyme organization in metabolic regulation, but the subject matter has been greatly broadened over the years, so that it now includes virtually all aspects of cell function. Macromolecular organization is critical notonly for the maintenance of various static cell structures, but also for the dynamic events that are coupled to key processes such as chromatin remodeling, transcription, RNA editing and transport, nuclear import/export, translation, protein degradation, cytoskeletal function, organelle transport, signal transduction, metabolic pathways, and apoptosis. Conference topics include the mechanisms of macromolecular interactions, and the responses of such mechanisms to changes in metabolic or hormonal status. The functional implications of interactions, such as channeling of metabolic intermediates or of signaling molecules, or the translocation of cellular components are of central interest, as are the characteristics of macromolecular complexes, both stable and transient. In previous conferences it has become very clear that many interactions may be altered or even lost when cells or tissues are disrupted for study, and a major interest is the development and application of methods to analyze interactions in theliving cell. This is an interdisciplinary conference. It attracts not only experimental scientists with interests and expertise ranging from biochemistry, cell biology, and molecular biology to biophysics, physics, and instrumentation, but also theoreticians and modelers. The interdisciplinary atmosphere produces excellent discussions and scientific interactions that are stimulating and highly valued by the participants. Eighteen excellent speakers and eight prominent discussion leaders have alreadyaccepted invitations to participate in the formal sessions of the next conference. A number of slots have been kept open for the most recent developments in this rapidly moving field.

关于大分子组织和细胞功能的戈登研究会议自 1987 年开始举办；这将是该系列的第八次会议。 最近一次会议于 1998 年 9 月在英国牛津大学皇后学院举行。该提案要求为下一次会议提供部分资金，下一次会议将于 2000 年 8 月 6 日至 11 日在牛津再次举行。这次会议的重点是细胞内组织细胞成分、该组织的原理和机制，以及该组织在细胞功能及其调节中的重要作用。 最初的会议集中讨论酶组织在代谢调节中的作用，但多年来主题已大大拓宽，因此现在几乎涵盖了细胞功能的所有方面。 大分子组织不仅对于维持各种静态细胞结构至关重要，而且对于与染色质重塑、转录、RNA编辑和运输、核输入/输出、翻译、蛋白质降解、细胞骨架功能等关键过程相关的动态事件也至关重要、细胞器运输、信号转导、代谢途径和细胞凋亡。 会议主题包括大分子相互作用的机制，以及这些机制对代谢或激素状态变化的反应。 相互作用的功能影响，例如代谢中间体或信号分子的通道，或细胞成分的易位，是人们关注的焦点，大分子复合物的特征（稳定和瞬时）也是如此。 在之前的会议中，已经非常清楚的是，当细胞或组织被破坏进行研究时，许多相互作用可能会改变甚至丢失，并且主要兴趣是分析活细胞中相互作用的方法的开发和应用。 这是一次跨学科的会议。 它不仅吸引了对生物化学、细胞生物学、分子生物学、生物物理学、物理学和仪器等领域具有兴趣和专业知识的实验科学家，而且还吸引了理论家和建模者。 跨学科的氛围产生了精彩的讨论和科学互动，受到参与者的启发和高度评价。 十八位优秀演讲嘉宾和八位杰出讨论领袖已接受邀请参加下届会议的正式会议。 为这个快速发展的领域的最新发展预留了许多位置。