POWRE: Signal Processing of Spontaneous Arrhythmias Acquired Chronically in an Adriamycin Model of Heart Failure

POWRE：阿霉素心力衰竭模型中慢性自发性心律失常的信号处理

• 批准号: 9973513
• 负责人: Stephanie Schuckers
• 金额: $ 8.5万
• 依托单位: West Virginia University Research Corporation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9973513&HistoricalAwards=false
• 关键词: POWRE; Signal; Processing; Spontaneous; Arrhythmias

9973513SchuckersOne to two million adults are affected in the United States by heart failure with 200,000 deaths annually. 30-50% of these deaths are sudden and have been attributed to cardiac electrical abnormalities. Electrocardiology, the study of electrical characteristics of the heart, plays a major role in prediction and prevention of sudden cardiac death. Although much research has been performed to attempt to predict sudden cardiac death, no long-term studies have tracked the electrocardiographic progression from normal to diseased state. Furthermore, little work has been done to analyze the electrocardiogram (ECG) in the weeks, days, and hours before a spontaneous event in order to establish a short-term electrophysiologic predictor of sudden cardiac death. If a sudden death episode could be predicted, long- and short-term interventions could be attempted to prevent the event. The overall goal of this proposal is to develop and use an adriamycin rabbit model of heart failure to study the electrocardiographic progression from normal to a sudden death event. Animals will be outfitted with a long-term implanted ECG system. ECGs will be recorded continuously for the lifetime of the animal through radiofrequency-telemetry. Classical ECG features as well as innovative features will be calculated by computer and monitored over the lifetime of the animal where particular attention will be paid to changes preceding an event. The main goal of this work will be the development of a short-term prediction scheme which could predict an impending event such that in the clinical setting preventions/interventions, like electrical therapies may be performed.

9973513Schuckers 在美国，一到两百万成年人患有心力衰竭，每年有 20 万人死亡。 其中 30-50% 的死亡是突然的，并且归因于心电异常。 心电学是对心脏电特性的研究，在预测和预防心源性猝死方面发挥着重要作用。 尽管已经进行了大量研究来尝试预测心源性猝死，但没有长期研究追踪心电图从正常状态到患病状态的进展。 此外，为了建立心源性猝死的短期电生理预测指标，在自发事件发生前数周、数天和数小时内分析心电图 (ECG) 的工作还很少。 如果可以预测猝死事件，则可以尝试采取长期和短期干预措施来预防该事件的发生。 该提案的总体目标是开发和使用阿霉素兔心力衰竭模型来研究从正常到猝死事件的心电图进展。动物将配备长期植入的心电图系统。将通过射频遥测技术在动物的一生中连续记录心电图。 经典心电图特征以及创新特征将通过计算机计算并在动物的一生中进行监测，其中将特别注意事件之前的变化。这项工作的主要目标是开发一种短期预测方案，该方案可以预测即将发生的事件，以便在临床环境中进行预防/干预，例如可以进行电疗。