REU Supplement: New Chiral Kemp's Acid Derivatives; Synthesis and Resolution of Potential Artificial Enzymes

REU 补充剂：新型手性 Kemp 酸衍生物；

• 批准号: 9911958
• 负责人: Bruce Baldwin
• 金额: $ 1.35万
• 依托单位: Spring Arbor College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-06-01 至 2001-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9911958&HistoricalAwards=false
• 关键词: REU; Supplement; New; Chiral; Kemp

9911958BaldwinThis proposal supports U.S.-Japan collaborative research between Dr. Bruce Baldwin of the Department of Chemistry, Spring Arbor College, Spring Arbor, MI and Dr. Takuji Hirose, Department of Applied Chemistry, Faculty of Engineering, Saitama University, Saitama, Japan. Dr. Baldwin will be supported for three months at Saitama University in order to develop new chemical sensors or recognition agents for chiral molecules. These new agents would be the natural extension of work previously completed in Japan by the host scientist, Dr. Takuji Hirose, and the PI.Conventional and enzymatic methods will be used to make the target molecules stereoselectively. The conventional approach will produce a racemic mixture of the target chiral molecules, separated by chiral column technology or as distereomeric salts. The enzymatic method capitalizes on the American PI's experience with enzymatically promoted organic chemistry, making an artificial enzyme using a natural enzyme.Molecular engineering of chemical recognition moieties is crucial for developing new materials having unique properties, molecular devices such as sensors, and stereocontrolled synthesis and separation systems. Chemists and industries in both the United States and Japan are intensely interested in these systems, so these studies will benefit the chemical knowledge of mutual importance to both countries. It is expected that the cooperation between these laboratories should foster future collaborations and promote international exchange of scientific resources and ideas.

9911958Baldwinthis提案支持美国密歇根州斯普林市Spring Arbor学院化学系的Bruce Baldwin博士与日本锡塔玛大学锡塔玛大学工程学院应用化学系的美国化学学院Bruce Baldwin博士。 Baldwin博士将在Saitama University的三个月内得到支持，以开发新的化学传感器或手性分子的识别剂。 这些新代理人将是主持人科学家Takuji Hirose博士在日本完成的工作的自然扩展，而PI.Concentional和酶促方法将用于立体地使目标分子立体化。 常规方法将产生靶性手性分子的外消旋混合物，该分子被手性柱技术或作为疾病盐隔开。 酶促方法利用了美国PI在酶促促进的有机化学方面的经验，使用天然酶制造人造酶。化学识别部分的分子工程对于开发具有独特特性的新材料，包括传感器和刻板的合成和分离系统的新材料至关重要。 美国和日本的化学家和行业对这些系统都非常感兴趣，因此这些研究将使两国相互重要性的化学知识受益。 预计这些实验室之间的合作应促进未来的合作并促进国际科学资源和思想的交流。