Shear Sensitivity of Bioluminescent Marine Cells

生物发光海洋细胞的剪切敏感性

• 批准号: 9730782
• 负责人: Michael Latz
• 金额: $ 40.06万
• 依托单位: University of California-San Diego Scripps Inst of Oceanography
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-15 至 2002-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9730782&HistoricalAwards=false
• 关键词: Shear; Sensitivity; Bioluminescent; Marine; Cells

9730782 Latz This interdisciplinary project is to examine the shear sensitivity of marine dinoflagellates, one of the most shear-sensitive organisms known. Luminescent dinoflagellates respond essentially instantaneously to mechanical stimulation via a unique and easily monitored bioluminescent effector system. These plant-like cells will be used as a model system for investigating fundamental questions in sensory biology with important engineering applications. The main questions relating to the mechanosensory signal transduction pathway are: (1) what is the role of G proteins in signal transduction; (2) how is applied mechanical stress related to fluid shear stress and cell strain; and (3) how is shear sensitivity affected by the cytoskeleton? ***

9730782 LATZ这个跨学科项目是为了检查海洋鞭毛藻的剪切敏感性，这是已知的最剪切敏感的生物之一。 发光的鞭毛鞭毛素基本上是通过独特且易于监测的生物发光效应器系统即时对机械刺激的反应。 这些植物样细胞将用作模型系统，用于研究具有重要工程应用的感觉生物学中的基本问题。 与机械感应信号转导途径有关的主要问题是：（1）G蛋白在信号转导中的作用是什么？ （2）如何使用与流体剪切应力和细胞应变有关的机械应力； （3）剪切敏感性如何受细胞骨架影响？ ***