U.S.- U.K. Cooperative Research: Molecular Modeling of Fundamental Mechanisms Governing Protein-Surface Adsorption

美英合作研究：蛋白质表面吸附基本机制的分子模拟

• 批准号: 9722505
• 负责人: Robert Latour
• 金额: $ 2.22万
• 依托单位: Clemson University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 1998-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9722505&HistoricalAwards=false
• 关键词: U.S.; U.K.; Cooperative; Research; Molecular

This one-year award supports US-UK cooperative research on engineering of biomaterials between Robert Latour of Clemson University and Larry Hench of Imperial College, London, United Kingdom. The objective of the research is to investigate model protein- surface adsorption behavior. The investigators will study the fundamental mechanisms governing protein adsorption at the three basic levels of protein structure: primary (amino acid sequence), secondary (configuration of molecular chains in helices, sheets, and loops), and tertiary (organization of secondary structures into the actual protein structure). Following the implantation of a biomaterial into the body, proteins rapidly adsorb onto the implant material's surface. Biologic response and the body's reaction to the implanted material are controlled by cellular reactions to this adsorbed protein layer. This project will advance our understanding of the mechanism controlling protein adsorption and adsorbed protein conformation and contribute toward the long-range goal of designing implant surfaces for controlled biologic response. It takes advantage of British expertise in biomaterials and protein sequencing at Imperial College and at the Interdisciplinary Research Center in Biomedical Materials at the University of London.

这项为期一年的奖项支持了克莱姆森大学罗伯特·拉图尔（Robert Latour）与英国伦敦帝国学院的拉里·赫奇（Larry Hench）之间的生物材料工程研究。 该研究的目的是研究模型蛋白质表面吸附行为。 研究人员将研究蛋白质结构的三个基本水平的管理蛋白质吸附的基本机制：初级（氨基酸序列），次级（螺旋，薄片和环中分子链的构型）和第三（将二级结构组织到实际蛋白质结构中）。 在将生物材料植入体内后，蛋白质迅速吸附到植入物材料的表面上。 生物学反应和人体对植入物质的反应受到对该吸附蛋白层的细胞反应的控制。 该项目将促进我们对控制蛋白质吸附和吸附蛋白质构象的机制的理解，并有助于设计植入物表面以进行控制生物学反应的远距离目标。 它利用英国在帝国学院的生物材料和蛋白质测序方面的专业知识，以及伦敦大学生物医学材料的跨学科研究中心。