CAA: Progesterone Receptor Gene Expression in the Brain

CAA：大脑中孕酮受体基因表达

• 批准号: 9707587
• 负责人: Barbara Attardi
• 金额: $ 5.31万
• 依托单位: Rockefeller University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-15 至 1998-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9707587&HistoricalAwards=false
• 关键词: CAA; Progesterone; Receptor; Gene; Expression

Attardi 9707587 Career Advancement Awards expand the opportunity for women researchers to advance their career. Dr. Attardi will use these funds to increase her knowledge of brain anatomy and to acquire state-of-the-art neuroanatomical techniques to allow her to examine the differential actions of progesterone leading to the facilitation or inhibition of the gonadotropin surge. The progesterone receptor is unusual among members of the steroid/thyroid family of nuclear receptors since, it exists in two isoforms, PRa and PRb, in all species except the rabbit. Moreover, it has been suggested that responsiveness to progesterone within a particular tissue could depend upon changes in the relative ratios of the two isoforms especially given that the two isoforms change developmentally and with endocrine manipulations. Since these studies used only tissue from the peripheral system, it is not clear whether the two isoforms are involved in the mechanism of progesterone action in neural tissue as well. Dr. Attardi will now examine both the presence and the regulation of the two progesterone isoforms in the brain and pituitary. She will determine the role that these two isoforms play in the modulating the ability of estrogen and progesterone to regulate gonadotropin secretion. Understanding the integration of this complex neuroendocrine mechanism is very important since it underlies the perpetuation of the species.

Attardi 9707587职业发展奖扩大了女性研究人员发展职业的机会。 Attardi博士将利用这些资金来增加她对脑解剖结构的了解，并获得最新的神经解剖技术，以使她能够检查孕激素的差异作用，从而促进或抑制促性腺激素激增。 在核受体的类固醇/甲状腺家族中，孕酮受体在两个同工型中存在于两个同工型，PRA和PRB中，除兔子以外，它存在于两个同工型中。 此外，已经提出，特定组织中对孕酮的反应性可能取决于两种同工型的相对比率的变化，特别是考虑到两种同工型在发育和内分泌操纵上发生变化。 由于这些研究仅使用外周系统的组织，因此尚不清楚这两种同工型是否也参与神经组织中孕酮作用的机理。 阿塔迪（Attardi）博士现在将检查大脑中两个孕酮同工型的存在和调节。 她将确定这两种同工型在调节雌激素和孕激素调节促性腺激素分泌的能力中起的作用。 了解这种复杂的神经内分泌机制的整合非常重要，因为它是该物种持续性的基础。