RPG: Dynamics of the Hypothalamic-Pituitary System in the Ranid Frogs

RPG：兰尼德青蛙下丘脑-垂体系统的动力学

• 批准号: 9707446
• 负责人: Pei-San Tsai
• 金额: $ 2.28万
• 依托单位: University of Connecticut
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-15 至 1999-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9707446&HistoricalAwards=false
• 关键词: RPG; Dynamics; Hypothalamic; Pituitary; System

The goal of this Research Planning Grant (RPG) is to examine the temporal pattern of endogenous gonadotropin-releasing hormone (GnRH) release in the bullfrog, Rana catesbeiana. Ranid flogs are highly unique in that they are the only tetrapods known to date to display a true physiological preference for continuous, rather than pulsatile, GnRH input for the maintenance of gonadotropin secretion. Based on this observation, it is hypothesized that unlike mammals and birds, reproduction in ranid frogs is driven by continuous release of endogenous GnRH. This hypothesis will be tested directly in this Research Planning Grant by investigating the temporal pattern of GnRH release from bullfrog hypothalamic slices using an in vitro perfusion system. The RPG results will provide the physiological basis for future investigations into the mechanisms by which continuous GnRH stimulation supports the overall reproductive functions. In addition, these data will facilitate the understanding of the dynamics of a potentially very novel hypothalamic-pituitary system.

这项研究计划补助金（RPG）的目的是检查内源性促性腺激素释放激素（GNRH）发行的时间模式，Rana Catesbeiana。 Ranid Flogs是高度独特的，因为它们是迄今为止已知的四脚架，以表现出对连续而不是脉动的GNRH输入来维持促性腺激素分泌的真正生理偏好。基于这一观察结果，假设与哺乳动物和鸟类不同，ranid蛙的繁殖是由内源性GNRH的连续释放驱动的。 通过使用体外灌注系统研究GNRH释放的GNRH释放的时间模式，该假设将直接在该研究计划赠款中进行检验。 RPG结果将为未来研究连续GNRH刺激支持总体生殖功能的机制提供生理基础。此外，这些数据将有助于理解潜在的非常新颖的下丘脑垂体系统的动力学。