CAREER: Tandem Repeats: Sequence Comparison and Search Algorithms

职业：串联重复：序列比较和搜索算法

• 批准号: 9623532
• 负责人: Gary Benson
• 金额: $ 20.5万
• 依托单位: Icahn School of Medicine at Mount Sinai
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-07-15 至 2000-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9623532&HistoricalAwards=false
• 关键词: CAREER; Tandem; Repeats; Sequence; Comparison

This project focuses on expanding the capabilities of the present (DNA) sequence analysis algorithms with respect to comparing sequences and detecting features. In particular, the project concentrates on:(1) developing methods for quantifying the relatedness of biological sequences under a broader model of mutational events, than the currently used substitution-indel model, and (2) improving methods for detecting tandem repeats in sequences. The Integrated Educational Plan of this CAREER Grant includes(a)developing a curriculum for graduate study in computational and mathematical biology, (b) developing courses and course materials, including lecture notes, exercises, programming projects and extensive bibliographies, that cover combinatorial and algorithmic topics in sequence alignment, DNA sequencing, DNA physical mapping, DNA physical mapping, and prediction of protein folding and RNA folding, and phylogenetic tree construction, (c) instituting a summer training course for new researchers in computational biology.***

该项目的重点是扩大当前（DNA）序列分析算法的功能，以比较序列和检测特征。 特别是，该项目集中于：（1）开发用于量化突变事件更广泛模型的生物学序列相关性的方法，而不是当前使用的替代 - indel模型，以及（2）改进用于检测序列中串联重复序列的方法。 The Integrated Educational Plan of this CAREER Grant includes(a)developing a curriculum for graduate study in computational and mathematical biology, (b) developing courses and course materials, including lecture notes, exercises, programming projects and extensive bibliographies, that cover combinatorial and algorithmic topics in sequence alignment, DNA sequencing, DNA physical mapping, DNA physical mapping, and prediction of protein folding and RNA折叠和系统发育树的建设，（c）为新研究人员设计了计算生物学的夏季培训课程。***