IGERT: Integrating Computational Science into Research in Biological Networks

IGERT：将计算科学融入生物网络研究

• 批准号: 0654108
• 负责人: Gary Benson
• 金额: $ 189.99万
• 依托单位: Trustees of Boston University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0654108&HistoricalAwards=false
• 关键词: IGERT; Integrating; Computational; Science; into; IGERT; Integrating; Computational; Science; into

The Integrative Graduate Education and Research Traineeship (IGERT) program in Bioinformatics at Boston University is a highly successful interdisciplinary training program that has served as a model for other universities. With this renewal award, it will shift research emphasis to focus on biological networks. Research in molecular biology is shifting fundamentally towards the study of complex, multi-component networks that underlie the living cell. These networks are modeled in terms of their component interactions, regulatory properties, sub-networks or pathways, and system dynamics. Important examples include 1) biochemical pathways of metabolism, 2) protein-DNA interactions that regulate gene transcription, and 3) signaling pathways for cellular response to hormones and other molecules. Training will continue to stress computational and mathematical sciences, biology, and biochemistry and will incorporate innovation in an initial year-long research experience to include intensive wet-lab training in high-throughput data generation techniques, a team oriented "grand challenge" bioinformatics research project, and laboratory validation of computational predictions. An international perspective will be fostered through student fellowships for extended visits with collaborating faculty at partner institutions in Germany, Japan, and Israel. To disseminate successful training methodologies, the Program will sponsor a National Bioinformatics Education Workshop. It will provide undergraduate research opportunities in faculty labs through partnership with Boston University programs targeted to underrepresented groups and it will develop high school outreach activities, curricula and workshops, combining mathematics and biology. IGERT is an NSF-wide program intended to meet the challenges of educating U.S. Ph.D. scientists and engineers with the interdisciplinary background, deep knowledge in a chosen discipline, and the technical, professional, and personal skills needed for the career demands of the future. The program is intended to catalyze a cultural change in graduate education by establishing innovative new models for graduate education and training in a fertile environment for collaborative research that transcends traditional disciplinary boundaries.

波士顿大学生物信息学的综合研究生教育和研究实习计划（IGERT）计划是一项非常成功的跨学科培训计划，曾是其他大学的典范。 通过这一续签奖，它将将研究重点转移到生物网络上。 分子生物学的研究从根本上转移到了活细胞构成的复杂的多组分网络的研究。这些网络是根据其组件相互作用，调节性能，子网络或途径以及系统动态建模的。 重要的例子包括1）代谢的生化途径，2）调节基因转录的蛋白-DNA相互作用，以及3）信号传导途径，用于细胞对激素和其他分子的细胞反应。 培训将继续强调计算和数学科学，生物学和生物化学，并将将创新纳入为期一年的研究经验中，以在高通量数据生成技术中进行密集的湿与LAB培训，这是一个面向团队的“盛大挑战”生物信息信息研究项目，以及计算预测的实验室验证。 将通过学生奖学金来培养国际观点，以与德国，日本和以色列合作机构的合作教师进行扩展访问。为了传播成功的培训方法，该计划将赞助国家生物信息学教育研讨会。 它将通过与针对代表人数不足的团体的波士顿大学计划的合作伙伴关系为教师实验室提供本科研究机会，并将开发高中外展活动，课程和研讨会，结合数学和生物学。 IGERT是一项旨在应对美国博士学位的挑战。具有跨学科背景的科学家和工程师，所选学科的深刻知识以及未来职业需求所需的技术，专业和个人技能。该计划旨在通过在肥沃的环境中建立创新的研究生教育和培训的新模型来促进研究生教育的文化变革，以超越传统学科界限的合作研究。