Biosynthesis of Secondary Metabolites from Blue-Green Algae

蓝绿藻次生代谢产物的生物合成

• 批准号: 9530794
• 负责人: Richard Moore
• 金额: $ 34.49万
• 依托单位: University of Hawaii
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-03-01 至 2000-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9530794&HistoricalAwards=false
• 关键词: Biosynthesis; Secondary; Metabolites; Blue; Green

The focus of this research is the biosynthetic study of the cyanobacterial toxins anatoxin a-(s)n Anabaena flos-aquae NCR 525-17, microcystin-LR in Microcystis aeruginosa PCC-7820, the cytotoxins cryptophycin-1 in Nostoc sp. GSV 224, cylindrocyclophane D in Cylindrospermum lichenforme ATCC 29204 and fungal alkaloids from the Stigonemataceae. One of the ultimate goals of the project will be to study biosynthetic processes at the enzymatic level. Also several unnatural C-substituted aspartic acids and beta-alanines will be evaluated as substrates for the `aberrant` biosynthesis of cryptophycin analogs. With this renewal award, the Synthetic Organic Program is supporting the research of Drs. Richard E. Moore and Thomas K. Hemscheidt of the Department of Chemistry at the University of Hawaii, Manoa. Drs. Moore and Hemscheidt will focus their work on biosynthetic studies of cyanobacterial toxins produced by blue-green algae. It is important to learn exactly how potent cyanobacterial toxins are produced , since poisonous blooms of blue-green algae in eutrophic freshwater and brackish lakes present serious environmental and health problems , not only to domestic animals and wildlife that live on the surrounding shores, but to human populations that depend on the water for drinking.

这项研究的重点是蓝细菌毒素ANATOXIN A-（S）N anabaena flos-aquae ncr 525-17，微囊藻胞藻固醇lr在铜绿孢子PCC-7820中，cytotoxins pcc-7820，cytotoxins pcc-7820，cytotoxins spspcypyphycincin-pcc-7820的生物合成研究。 GSV 224，圆柱形cylindrospermum lichenforme ATCC中的cylindrocyclophane D和stigonemataceae的真菌生物碱。 该项目的最终目标之一是在酶促水平上研究生物合成过程。 同样，将评估几种不自然的c取代的天冬氨酸和β-丙氨酸，作为隐藻霉素类似物的“异常”生物合成的底物。 通过此续签奖，合成有机计划正在支持DRS的研究。 Manoa夏威夷大学化学系的Richard E. Moore和Thomas K. Hemscheidt。 博士。 Moore和Hemscheidt将把他们的工作集中在蓝绿色藻类产生的蓝细菌毒素的生物合成研究上。 重要的是要准确了解如何产生有效的蓝细菌毒素，因为在富营养化的淡水和咸湖中，蓝绿色藻类的有毒花朵会带来严​​重的环境和健康问题，这不仅对生活在周围海岸上的家畜和野生动植物，而且对依赖水的人类种群而言。