Deconstructing the brain circuits of reward-seeking

解构寻求奖励的大脑回路

• 批准号: DE230100401
• 负责人: Dr Erin Campbell
• 金额: $ 27.74万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-11-14 至 2026-12-11
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE230100401
• 关键词: Deconstructing; brain; circuits; reward; seeking

This project aims to deconstruct the brain circuits that shape reward-seeking behaviour in different environments. The anticipated significance of this project is to provide mechanistic insights into why we choose to seek rewards in safe, but not dangerous environments. Expected outcomes include answering fundamental questions about how the environment shapes our behaviour by identifying projection cell subtypes important for reward-seeking, characterising their neuronal activity and precisely defining their molecular phenotype. The benefits of this project are expected to provide a new knowledge base for understanding decision-making in a constantly changing world.

该项目旨在解构在不同环境中塑造寻求奖励行为的大脑回路。该项目的预期意义是提供机制性见解，解释为什么我们选择在安全而不是危险的环境中寻求奖励。预期结果包括通过识别对寻求奖励很重要的投射细胞亚型、表征其神经元活动并精确定义其分子表型来回答有关环境如何塑造我们行为的基本问题。该项目的好处预计将为理解不断变化的世界中的决策提供新的知识库。