Role of Serotonin in Feeding Arousal in a Mollusc

血清素在软体动物摄食唤醒中的作用

• 批准号: 9319927
• 负责人: Richard Satterlie
• 金额: $ 27.74万
• 依托单位: Arizona State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-08-01 至 1998-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9319927&HistoricalAwards=false
• 关键词: Role; Serotonin; Feeding; Arousal; Mollusc

9319927 Satterlie Behavioral arousal in animals and humans occurs when there is a change in several independent behaviors so that the overall behavioral output is more focussed or efficient. Behavioral arousal is an important issue that is not well-understood at the cellular level. In the marine mollusc Clione when prey is nearby, a feeding arousal response occurs in which there is a decreased threshold for starting the feeding behavior, an increase in swimming speed for more efficient prey capture, an increase in heart rate and an inhibition of the withdrawal response. This work will investigate the cellular mechanisms in the nervous system that give rise to this change in behavioral state and examine the role of the brain chemical serotonin in this behavior. Clione is an excellent animal in which to study behavioral arousal because the neural circuits that underlie the component behaviors (feeding, swimming, and withdrawal) have already been worked out and the level of individual nerve cells by the PI and others. The PI has also shown that injection of serotonin into the animal results in feeding arousal behavior and that there are cells in the Clione nervous system that contain serotonin. ***

9319927 Satterlie 当几种独立行为发生变化时，动物和人类就会发生行为唤醒，从而使整体行为输出更加集中或有效。 行为唤醒是一个在细胞水平上尚未得到充分理解的重要问题。在海洋软体动物 Clione 中，当猎物在附近时，会发生进食唤醒反应，其中开始进食行为的阈值降低，游泳速度增加以更有效地捕获猎物，心率增加并抑制退缩回复。 这项工作将研究神经系统中引起这种行为状态变化的细胞机制，并检查大脑化学血清素在这种行为中的作用。 Clione 是研究行为唤醒的优秀动物，因为 PI 和其他人已经研究出了构成行为组成部分（进食、游泳和退缩）的神经回路以及单个神经细胞的水平。 PI 还表明，向动物注射血清素会导致进食唤醒行为，并且 Clione 神经系统中存在含有血清素的细胞。 ***