Reversing neuronal cell vulnerability common to three types of ataxias: Christianson Syndrome, Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS), and Spinocerebellar ataxia type 6 (SCA6)

逆转三种共济失调常见的神经元细胞脆弱性：克里斯蒂安森综合征、常染色体隐性遗传的沙格奈痉挛性共济失调 (ARSACS) 和脊髓小脑性共济失调 6 型 (SCA6)

• 批准号: 498209
• 负责人: Kanagasabai Atchaya
• 金额: $ 1.27万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-12-01 至 2023-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=498209&lang=en
• 关键词: Arsacs; Ataxia; Cerebellum; Christianson Syndrome; Eaat1; Endosomes; Neurodegeneration; Nhe6; Purkinje Cells; Sca6

Cerebellar ataxias are devasting disorders involving progressive movement impairment. Different forms of ataxia arise from various mutations in several genes, yet the disease progress can be similar. Most ataxias are rare, affecting tens of thousands worl

小脑共济失调正在破坏涉及进行性运动障碍的疾病。多种基因的各种突变引起了不同形式的共济失调，但疾病进展可能相似。大多数共济失调很少