Synthesis of Vitamin K Models

维生素 K 模型的合成

• 批准号: 9302560
• 负责人: Paul Dowd DECEASED
• 金额: $ 30.5万
• 依托单位: University of Pittsburgh
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-06-01 至 1996-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9302560&HistoricalAwards=false
• 关键词: Synthesis; Vitamin; Models

This grant from the Organic Dynamics Program supports the continuing work of Professor Paul Dowd at the University of Pittsburgh to study a new experimental model for the vitamin K-dependent carboxylation to further unravel its essential role in the complex events of blood clotting. The oxygenation of vitamin K will be studied using isotopically labeled oxygen. This will be followed by other oxygenations and investigations of the nature of the base(s) involved and of the effects of other strong bases on activity. Intramolecular models, micelles, liposomes and environments that mimic those of the membrane locale of the vitamin K action will also be explored. %%% In this project Dr. Paul Dowd will conduct an extensive set of oxygenation studies, using labeled molecular oxygen, to unravel the complex mechanism of blood clotting in which vitamin K plays an essential role. Not only is a new experimental model used for the action of vitamin K, but also its environment is modelled to mimic the membrane locale where the vitamin is active. The influence of strong bases on vitamin K's activity is an important part of this study.

有机动力学计划的这项赠款支持匹兹堡大学保罗·道德（Paul Dowd）教授的持续工作，以研究一种新的实验模型，用于维生素K依赖性羧化，以进一步揭示其在复杂的血液凝结事件中的重要作用。将使用同位素标记的氧气研究维生素K的氧合。随后将进行其他氧合和对所涉及的碱的性质以及其他强碱基对活动的影响的研究。还将探索模仿维生素K作用的膜位置的分子内模型，胶束，脂质体和环境。 在这个项目中，保罗·道德（Paul Dowd）博士将使用标记的分子氧进行广泛的氧合研究，以揭示维生素K起着至关重要的作用的血液凝结的复杂机制。不仅是一种用于维生素K的作用的新实验模型，而且其环境也被建模以模仿维生素活性的膜位置。强碱对维生素K活性的影响是本研究的重要组成部分。