Synthesis of Vitamin K Models

维生素 K 模型的合成

• 批准号: 9014322
• 负责人: Paul Dowd DECEASED
• 金额: $ 19.8万
• 依托单位: University of Pittsburgh
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-01 至 1993-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9014322&HistoricalAwards=false
• 关键词: Synthesis; Vitamin; Models

The Organic Dynamics program will support Professor Paul Dowd's study of "Synthesis of Vitamin K Models" in the Chemistry Department at the University of Pittsburgh. Vitamin K is required for blood clotting, where it is an essential cofactor in the complex enzymic sequence known as the blood clotting cascade. This study will explore a new experimental model for the vitamin K-dependent carboxylation reaction since in the absence of carboxylation blood clotting is inhibited. A variety of methods are being used to study the new experimental model for the vitamin K-dependent carboxylation reaction, including inter- and intramolecular condensation reactions, oxygen labelling experiments, exploration of new strong bases, and new oxygenation reactions. Model experiments will determine whether molecular oxygen triggers the carboxylation reaction by reacting with the anionic form of vitamin K hydroquinone to produce vitamin K oxide, whose formation provides the energy necessary to furnish a base sufficiently strong to effect carboxylation.

有机动力学计划将支持保罗·道德（Paul Dowd）教授在匹兹堡大学化学系中对“维生素K模型合成”的研究。 维生素K是血液凝结所必需的，它是复杂酶序列中必不可少的辅助因子，称为血液凝结级联反应。 这项研究将探索一种新的实验模型，用于维生素K依赖性羧化反应，因为在没有羧化的情况下，血液凝结受到抑制。 正在使用多种方法来研究维生素K依赖性羧化反应的新实验模型，包括分子间和分子内冷凝反应，氧标记实验，新的强碱基的探索以及新的氧合反应。 模型实验将确定分子氧是否通过与维生素K氢喹酮的阴离子形式反应产生维生素K氧化物来触发羧化反应，其形成提供了提供良好基础以实现羧化的碱基提供必要的能量。