Long-Range Electron Transfer Reactions in Proteins

蛋白质中的长程电子转移反应

• 批准号: 9221603
• 负责人: Jorge Colón
• 金额: $ 3.2万
• 依托单位: University of Puerto Rico
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-01 至 1994-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9221603&HistoricalAwards=false
• 关键词: Long; Range; Electron; Transfer; Reactions

This award is the starter grant increment of Dr. Colon's Postdoctoral Fellowship in Chemistry. The research will result in a better understanding of the reorganizational energy of molecules as a function of distance in long range electron transfer reactions. Electron transfer rates will be measured for Re(II) and Re(I) coordinated to human myoglobin variants. The effects of distance of electron transfer and of the electronic coupling in the protein on electron transfer rates will be evaluated. Flash-quench and photoinduced electron transfer experiments will be used to obtain the desired rates. %%% Biological electron transfer plays major roles in respiration, photosynthesis, and immune response. The research to be carried out will provide a better insight into these important reactions. These insights will be helpful to scientists studying many aspcects of human health.

该奖项是Colon博士的化学博士后研究金的首发补助金。这项研究将更好地理解分子的重组能，这是远程电子转移反应中距离的函数。 将测量RE（II）和RE（i）与人肌红蛋白变体配位的电子传输速率。 将评估电子传递和电子耦合蛋白质中电子转移速率的距离的影响。闪电液和光诱导的电子传输实验将用于获得所需的速率。 %% %%生物电子转移在呼吸，光合作用和免疫反应中起着重要作用。要进行的研究将更好地了解这些重要的反应。这些见解将有助于研究许多人类健康的低调。