Interrogating protein hydration by terahertz time-domain spectroscopy

通过太赫兹时域光谱研究蛋白质水合

• 批准号: LP160100325
• 负责人: Prof Vincent Wallace
• 金额: $ 18.74万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-11-09 至 2020-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP160100325
• 关键词: Interrogating; protein; hydration; terahertz; time

Interrogating protein hydration by terahertz time-domain spectroscopy. This project aims to develop advanced terahertz time-domain spectroscopy (THz-TDS) techniques to understand how a protein’s interaction with excipients in solution can alter the hydration layers around them and how this affects properties such as viscosity and stability. THz-TDS can detect overlapping extended hydration layers around proteins, revealing new knowledge in protein-protein interactions and protein behaviour in an aqueous environment. The intended outcome is to use THz-TDS to better understand how proteins such as monoclonal antibodies interact in high concentration solutions, and in doing so make better medicines.

Terahertz时域光谱镜的蛋白质旨在开发高级的时间域光谱，以了解溶液中的蛋白质如何改变周围的水合层可以在水性环境中检测蛋白质蛋白质周围的覆盖层。