Palladium-Dependent Approaches to Enantiomerically Pure Carbocyclic Analogues of Purine Nucleosides

依赖钯的方法制备对映体纯的嘌呤核苷碳环类似物

• 批准号: 8908212
• 负责人: Donald Deardorff
• 金额: $ 11.41万
• 依托单位: Occidental College
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-07-01 至 1992-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8908212&HistoricalAwards=false
• 关键词: Palladium; Dependent; Approaches; Enantiomerically; Pure

The research of Dr. Donald Deardorff is supported by the Synthetic Organic Chemistry Program. Deardorff is an associate professor of chemistry at Occidental College. He is studying new methods for the stereocontrolled preparation of carbocyclic analogues of purine nucleosides, molecules having important applications in the development of new medicines. In particular, new approaches using organopalladium chemistry will be examined. The goal of the project is to develop novel synthetic strategies which permit facile, stereocontrolled access to both saturated and unsaturated carbocyclic analogues of purine nucleosides. Strategies to be used make reiterative use of (pi-allyl)palladium chemistry. Natural product targets used to showcase developed synthetic technologies include neplanocin and aristeromycin. The introduction of chirality into the synthesis will be accomplished by employing enzymatic reactions to prepare key starting materials.

Donald Deardorff博士的研究得到了合成有机化学计划的支持。 Deardorff是西方学院化学副教授。 他正在研究嘌呤核苷的碳环类似物的立体控制制备，在新药物开发中具有重要应用的分子。特别是，将检查使用细胞核化学的新方法。 该项目的目的是开发新型的合成策略，这些策略允许嘌呤核苷的饱和和不饱和碳环类似物易于立体控制。 使用的策略可以重复使用（Pi-Alyl）钯化学。 用于展示开发的合成技术的天然产物靶标包括内皮蛋白和芳香霉素。 将手性的引入将通过采用酶促反应来准备关键的起始材料来实现合成。