Presidential Young Investigator Award/Role of Metal Ions in Enzyme Action

总统青年研究员奖/金属离子在酶作用中的作用

• 批准号: 8857455
• 负责人: William Armstrong
• 金额: $ 24万
• 依托单位: University of California-Berkeley
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-07-15 至 1992-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8857455&HistoricalAwards=false
• 关键词: Presidential; Young; Investigator; Award; Role

This Presidential Young Investigator Award from the Inorganic, Bioinorganic and Organometallic Chemistry Program will support research in biologically relevant inorganic chemistry. The emphasis of the project will be the elucidation of the role of metal ions in important biological transformations. Of particular interest is the participation of transition metal ions in the terminal steps of the reduction of dioxygen by cytochrome oxidase and the evolution of oxygen by the photosynthetic apparatus. Small molecule analogs of the metal centers of these and other metalloproteins, especially manganese-containing proteins, will be synthesized and characterized. The general strategy to be taken will involve the design and synthesis of organic ligands, preparation and purification of their complexes with transition metals, and thorough characterization of such systems by a variety of structural, magnetic, and spectroscopic techniques. In addition to the systems mentioned above, others of interest include the magnetically-coupled siroheme and iron-sulfur cluster in sulfite reductase, and the participation of nickel in hydrogenase and methanogenesis activity. Finally, the role of low valent vanadium in catalyzing the conversion of dinitrogen to ammonia and hydrazxine will be explored. Comparison of the spectroscopic and chemical properties of the model compounds is expected to yield valuable insight into the detailed workings of the modeled biological systems.

无机、生物无机和有机金属化学项目颁发的总统青年研究员奖将支持生物相关无机化学的研究。 该项目的重点是阐明金属离子在重要生物转化中的作用。 特别令人感兴趣的是过渡金属离子参与细胞色素氧化酶还原双氧和光合作用装置放出氧气的最终步骤。 这些和其他金属蛋白，特别是含锰蛋白的金属中心的小分子类似物将被合成和表征。 采取的总体策略将涉及有机配体的设计和合成，其与过渡金属的配合物的制备和纯化，以及通过各种结构、磁性和光谱技术对此类系统进行彻底表征。 除了上述系统之外，其他令人感兴趣的系统还包括亚硫酸盐还原酶中的磁耦合西罗血红素和铁硫簇，以及镍在氢化酶和产甲烷活性中的参与。 最后，探讨低价钒在催化二氮转化为氨和肼中的作用。 模型化合物的光谱和化学性质的比较预计将为建模生物系统的详细工作原理提供有价值的见解。