Biomimetic Chemistry Relevant to Photosystem II

与光系统​​II相关的仿生化学

• 批准号: 0616812
• 负责人: William Armstrong
• 金额: $ 43.1万
• 依托单位: Boston College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-15 至 2011-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0616812&HistoricalAwards=false
• 关键词: Biomimetic; Chemistry; Relevant; Photosystem; II

Dr. William H. Armstrong, Chemistry Department, Boston College, is supported by the Inorganic, Bioinorganic, and Organometallic Chemistry Program of the Chemistry Division for a study of biomimetic chemistry relevant to Photosystem II. The overall objective is to gain a sharper understanding of water oxidation that is catalyzed by Photosystem II, whose active site contains an oxygen-bridged manganese cluster. Replicas of the tetramanganese site in Photosystem II will be prepared. Their behavior under redox and pH changes will be investigated to learn how the enzyme cluster may respond to changes experienced during the catalytic cycle. Hypotheses regarding the mechanism of O-O bond formation and release of dioxygen will be evaluated using the model compounds. Emphasis will be placed on investigating the roles played by chloride and calcium cofactors.Photosynthesis harnesses sunlight energy to drive the production of atmospheric oxygen and the conversion of carbon dioxide into organic material. The focus of this research is to gain a greater understanding of how Photosystem 2 oxidizes water to oxygen. This knowledge may aid the effort to make artificial photosynthetic cells that efficiently split water to produce oxygen and hydrogen gas. Such an advance would facilitate the conversion of our energy economy to hydrogen. Graduate, undergraduate, and postdoctoral students will gain training on this project. In addition, high school students will be given the opportunity to participate in the project.

波士顿学院化学系的 William H. Armstrong 博士得到化学系无机、生物无机和有机金属化学项目的支持，进行与光系统 II 相关的仿生化学研究。总体目标是更深入地了解光系统 II 催化的水氧化，其活性位点包含氧桥锰簇。将制备光系统 II 中四锰位点的复制品。我们将研究它们在氧化还原和 pH 变化下的行为，以了解酶簇如何响应催化循环期间经历的变化。关于 O-O 键形成和分子氧释放机制的假设将使用模型化合物进行评估。重点将放在研究氯化物和钙辅助因子所发挥的作用。光合作用利用阳光能量来驱动大气中氧气的产生以及二氧化碳转化为有机物质。这项研究的重点是更好地了解光系统 2 如何将水氧化为氧气。这些知识可能有助于制造能够有效分解水以产生氧气和氢气的人造光合细胞。这样的进步将促进我们的能源经济向氢的转变。研究生、本科生和博士后学生将接受该项目的培训。此外，高中生将有机会参与该项目。