Regulation of Adenylyl Cyclase Signalling in Pulmonary Artery and Right Ventricle in Persistent Pulmonary Hypertension of the Newborn

新生儿持续性肺动脉高压肺动脉和右心室腺苷​​酸环化酶信号传导的调节

• 批准号: 286973
• 负责人: Dakshinamurti Shyamala
• 金额: $ 7.29万
• 依托单位: Manitoba Institute of Child Health
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-03-01 至 2015-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=286973&lang=en
• 关键词: Adenylyl Cyclase; Camp; Hypoxia; Persistent Pulmonary Hypertension Of The Newborn; Prostacyclin Receptor; Pulmonary Arterial Hypertension; Regulation Of Receptor-G-Protein Coupling; Right Ventricular Function

The newborn lung is very sensitive to low levels of oxygen. In infants who do not receive enough oxygen at birth, the low oxygen level causes lung blood vessels to go into spasm. Then blood cannot flow through the lung for gas exchange. This causes the he

新生儿的肺对低氧水平非常敏感。对于出生时没有获得足够氧气的婴儿，低氧水平会导致肺血管痉挛。然后血液就不能流经肺部进行气体交换。这导致他