Functional regulation of pulmonary arterial thromboxane receptor by post-translational modification, in hypoxic persistent pulmonary hypertension of the newborn

新生儿缺氧持续性肺动脉高压中翻译后修饰对肺动脉血栓素受体的功能调节

• 批准号: 207349
• 负责人: Dakshinamurti Shyamala
• 金额: $ 7.29万
• 依托单位: Manitoba Institute of Child Health
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-03-01 至 2012-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=207349&lang=en
• 关键词: Hypoxia; Molecular Modelling; Persistent Pulmonary Hypertension Of The Newborn; Pulmonary Arterial Hypertension; Regulation Of Receptor-G-Protein Coupling; Serine Phosphorylation; Site-Directed Mutagenesis; Thromboxane Receptor Sensitization

The newborn lung is very sensitive to low oxygen levels. In the lungs of infants who do not receive sufficient oxygen at birth, low oxygen makes the lung blood vessels go into spasm, so blood cannot flow through the lung for gas exchange. This causes the

新生儿的肺对低氧水平非常敏感。婴儿出生时肺部没有得到足够的氧气，低氧会使肺部血管痉挛，血液无法流经肺部进行气体交换。这导致