Purchase of an ORD/CD Spectropolarimeter

购买 ORD/CD 分光旋光计

• 批准号: 8820216
• 负责人: Lawrence Barton
• 金额: $ 5.57万
• 依托单位: University of Missouri-Saint Louis
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-01-01 至 1990-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8820216&HistoricalAwards=false
• 关键词: Purchase; ORD; CD; Spectropolarimeter

The phenomena of Circular Dichroism (CD) and Optical Rotatory Dispersion (ORD) are studied by chemists in order to gain special insight into the specific arrangement of atoms within molecules that possess the property of chirality. A molecule is said to be chiral when it is not superimposable on its mirror image. A crucial instrument used to study the phenomena is the CD/ORD spectropolarimeter. Access to the instrument is essential to those chemists carrying out modern research involving chiral molecules. This award from the Chemistry Shared Instrumentation Program will help the Department of Chemistry at the University of Missouri at St. Louis to acquire a CD/ORD spectropolarimeter. The areas of chemical research that will be enhanced by the acquisition include the following: 1) Structure and spectroscopy of high-symmetry aqueous lanthanide complexes 2) Circular dichroism of organo-deuterium compounds 3) Synthesis and structure of chiral thioaryl allenes 4) Detecting conformational changes during iron removal from transferrin 5) Orientation of substrates and active sites in artificial enzymes.

化学家研究圆二色性 (CD) 和旋光色散 (ORD) 现象，以便深入了解具有手性性质的分子内原子的特定排列。 当分子不能与其镜像重叠时，就称其为手性分子。 用于研究该现象的重要仪器是 CD/ORD 分光旋光计。 对于进行涉及手性分子的现代研究的化学家来说，使用该仪器至关重要。 化学共享仪器计划的这一奖项将帮助密苏里大学圣路易斯分校化学系购买一台 CD/ORD 分光旋光仪。 此次收购将增强的化学研究领域包括：1）高对称性水性镧系元素配合物的结构和光谱学2）有机氘化合物的圆二色性3）手性硫代芳基丙二烯的合成和结构4）检测构象从转铁蛋白去除铁过程中的变化 5) 人工酶中底物和活性位点的方向。