Calcium Channels: NYAS Conference; on July 18-20, 1988, London, England.

钙通道：NYAS 会议；

• 批准号: 8719443
• 负责人: Peter Hess
• 金额: $ 0.5万
• 依托单位: New York Academy of Sciences
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-05-01 至 1989-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8719443&HistoricalAwards=false
• 关键词: Calcium; Channels; NYAS; Conference; July

This conference sponsored by the New York Academy of Sciences will highlight the remarkable progress achieved over the last few years concerning calcium channels in excitable tissues. Advances were mainly possible because of the development of new Ca++ channel ligands and of new methods for the detailed functional investigation of single Ca++ channel molecules. Thus, several distinct Ca++ channel types with different biophysical, physiological, pharmacological and regulatory properties have been identified. New models for the mechanisms of ion permeation and channel gating have been developed. New high-affinity ligands have allowed the chemical purification and elucidation of the subunit composition of at least one channel type, the localization of channel distribution as well as the observation of Ca++ channel expression during development and in various diseases. Additionally, antibodies against Ca++ channels have been implicated in the pathogenesis of Lambert-Eaton Myasthenic Syndrome, and a specific absence of Ca++ channels has been demonstrated in muscular dysgenesis. Ca++ channel study has evolved into a truly multi-disciplinary effort. The conference will bring together scientists from neurobiology, biochemistry, molecular biology, physiology and pharmacology, each contributing a vital part to the understanding of this relevant biological signalling pathway.

这次会议由纽约科学院主办，将重点介绍过去几年在可兴奋组织钙通道方面取得的显着进展。 之所以能够取得进展，主要是因为新的 Ca++ 通道配体的开发以及对单个 Ca++ 通道分子的详细功能研究的新方法的开发。 因此，已经鉴定出具有不同生物物理、生理学、药理学和调节特性的几种不同的Ca++通道类型。 离子渗透和通道门控机制的新模型已经开发出来。 新的高亲和力配体允许化学纯化和阐明至少一种通道类型的亚基组成、通道分布的定位以及在发育期间和各种疾病中观察Ca++通道表达。 此外，针对 Ca++ 通道的抗体与 Lambert-Eaton 肌无力综合征的发病机制有关，并且在肌肉发育不全中已证明 Ca++ 通道的特异性缺失。 Ca++ 通道研究已发展成为真正的多学科工作。 这次会议将汇集来自神经生物学、生物化学、分子生物学、生理学和药理学的科学家，他们每个人都为理解这一相关的生物信号通路做出了重要贡献。