Defining the molecular basis for Salmonella persistence

定义沙门氏菌持久性的分子基础

• 批准号: DP230102796
• 负责人: Prof Ian Henderson
• 金额: $ 41.55万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-19 至 2026-01-18
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230102796
• 关键词: Defining; molecular; basis; Salmonella; persistence

Salmonella infections in animals and humans place significant burdens on the agri-food and healthcare sectors. All mammals and avian species can become chronically infected with Salmonella and such chronic carriage is a reservoir for disease and outbreaks in other animals and humans. Significant gaps in our understanding of Salmonella infection remain, including the molecular mechanisms involved in establishing a chronic carrier state. We identified several Salmonella specific genes and subsequent murine studies revealed that a Salmonella mutant lacking these genes is attenuated in mice and especially in the gallbladder. In this project we seek to understand the molecular basis for attenuation and the contribution of each protein to disease

动物和人类的沙门氏菌感染给农业食品和医疗保健部门带来了沉重负担。所有哺乳动物和鸟类都可能慢性感染沙门氏菌，这种慢性携带是其他动物和人类疾病和爆发的储存库。我们对沙门氏菌感染的理解仍然存在重大差距，包括建立慢性携带状态所涉及的分子机制。我们鉴定了几个沙门氏菌特异性基因，随后的小鼠研究表明，缺乏这些基因的沙门氏菌突变体在小鼠中，特别是在胆囊中的毒力减弱。在这个项目中，我们试图了解减弱的分子基础以及每种蛋白质对疾病的贡献