Human Leukocyte Antigen-A and -B regulation of Natural Killer cell function

人类白细胞抗原 A 和 B 对自然杀伤细胞功能的调节

• 批准号: DP230103117
• 负责人: Prof Andrew Brooks
• 金额: $ 57.06万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230103117
• 关键词: Human; Leukocyte; Antigen; regulation; Natural

The aim of this project is to determine how genetic variation in the genes encoding cell surface receptors expressed by innate lymphocytes and the molecules they recognise diversifies their capacity to sense and respond to infection. This knowledge is critical for understanding why there are intrinsic differences between individuals with respect to their capacity to respond to different types of infection and will ultimately inform our capacity to better deploy personalised medicines.

该项目的目的是确定由先天淋巴细胞表达的细胞表面受体的基因中的遗传变异以及他们认识到的分子如何使他们感知和应对感染的能力多样化。这些知识对于理解为什么个体之间在对不同类型的感染反应的能力方面存在内在差异至关重要，并最终将为我们更好地部署个性化药物的能力提供信息。