Zebrafish tp53 Mutants Recapitulate Li-Fraumeni Syndrome Phenotypes and Provide a Preclinical Platform for Evaluating Tumor Preventive Compounds

斑马鱼 tp53 突变体重现了 Li-Fraumeni 综合征表型，并为评估肿瘤预防化合物提供了临床前平台

• 批准号: 477539
• 负责人: Kobar Kimberly
• 金额: $ 7.65万
• 依托单位: Children's Hospital of Eastern Ontario Research Institute Inc
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-10-01 至 2025-10-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=477539&lang=en
• 关键词: Cancer; Drug Discovery; Genetic Models; Li-Fraumeni Syndrome; P53; Zebrafish

Li-Fraumeni Syndrome (LFS) is an inherited disorder typically caused by mutations in the TP53 gene in every cell of the body. These mutations greatly increase the risk of developing cancer, usually during childhood. p53, the protein product of the TP53 ge

Li-Fraumeni 综合征 (LFS) 是一种遗传性疾病，通常由身体每个细胞的 TP53 基因突变引起。这些突变极大地增加了患癌症的风险，通常是在儿童时期。 p53，TP53基因的蛋白质产物