基于生长物质的选择性非完全润湿机制可控制备AXn型无定形 “胶体分子”

Controllable synthesis of “colloidal molecules” is the foundation of realizing its function regulation, but it is one of the most challenging work in the field of colloid science. Controlled nucleation and growth is an efficient way to achieve the controllable synthesis of crystalline “colloid molecules”, but it is still not applicable for the amorphous overgrown materials that greatly limits their applications. In this project, we device a novel and general technique for the controllable preparation of adjustable valency porous amorphous “colloidal molecules” based on the “selective non-completely wetting” of the finely-tuned hydrophobicity-hydrophilicity micelle/organosilica assemblies on the surface of seed nanoparticles . The function of “selective non-completely wetting” on the regulation of valency of “colloid molecules” will be systematically investigated to establish an universal method to construct amorphous “colloid molecules” with adjustable valency. Furthermore, realize the regulation of the pore structures of the “colloidal molecules” through the template function of pore-forming agent. Finally, the surface plasma resonance absorbtion peak of these newly-structured “colloid molecules” will be investigated to reveal the relationships and regulation rules of composition-structure-surface plasma resonance absorbtion, and provide the scientific basis from theory to experiment to realize its applications in the field of fluorescence imaging and near infrared thermal therapy.

“胶体分子”的可控制备是实现其功能调控的基础，也是目前胶体粒子研究领域中最具挑战性的工作之一。可控的成核和生长是实现可控制备的主要途径，但主要用于合成结晶性纳米晶，对无定形化合物组分为生长物质的“胶体分子”仍不适用，这大大制约了这类新型胶体粒子的发展。本项目拟利用亲疏水性可多重调控的致孔剂胶束/有机硅组装体在种子粒子表面的“选择性非完全润湿”，可控制备共价键可调的多孔有机硅基无定形“胶体分子”。着重研究“选择性非完全润湿”在“胶体分子”共价键调控中的作用机理，建立基于选择性非完全润湿机制构筑共价键可调的无定形“胶体分子”的普适性方法；再结合致孔剂的模板作用，实现对“胶体分子”孔道结构的调控；在此基础上，研究新型结构“胶体分子”的表面等离子体共振峰，揭示其组成-结构-等离子体共振峰的相关性及其调控规律，最终为实现其荧光成像、近红外热疗等应用提供从理论到实验的科学依据。

在青年基金的支持下，本项目从有机硅烷偶联剂的两亲性调控及水解-缩合反应动力学的研究上入手，以不同组成的纳米粒子（Fe3O4、Au、Ag、聚苯乙烯等）为种子粒子，通过致孔剂调控有机硅烷偶联剂在种子粒子上的“非完全润湿”成核；同时结合有机硅烷偶联剂的水解-缩合反应动力学控制，成功制备了共价键数目n可调的AXn型Fe3O4（Au、Ag、PS）-介孔有机硅“胶体分子”。研究了不同结构AXn型“胶体分子”的形成机理及其共价键数目n的调控方法，建立了基于选择性非完全润湿机制构筑共价键可调的无定形“胶体分子”的机制。本研究为共价键可调的无定形“胶体分子”的设计和可控制备新的方法和理论指导。通过本项目的研究，我们获得了丰硕的成果，完成了本项目的研究目标。.项目执行期间，共发表SCI论文6篇，中文论文3篇，另有4篇研究论文正/或准备投稿至SCI期刊，申请中国发明专利8项，其中3项已授权。

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