基于多模态稀土纳米探针的高能碳离子控释系统用于隐匿性淋巴微转移的诊疗研究

lanthanide element shows similar chemical property and atomic radius but different physical property, and thus they could be replaced in the crystal lattice and realize multifunction in one nanocrystal. Moreover, high energy carbon ion beam exhibites high line energy transfer(LET) and thus could effectively break the double strand DNA. Based on these characteristics of lanthanide nanocrystal and carbon ion, we designed a kind of nanocomposite that could be used as multimodal imaging tracer and also as carbon ion triggered drug release system, which facilitated the multimodal imaging and the radiochemotherapy of lymphatic micrometastasis. The stable dispersible nanocoposite is considered to realize high tissue resolution and quantificational imaging and to present highly specific site of drug release without depth limitaton. We try to further improve the early detection rate and metastasis control rate through multimodal imaging and triggered drug release using our nanocomposite.

基于稀土元素的相似性和多功能性、高能碳离子束的高线性能量传递特点以及高效切断DNA双链的能力，利用纳米技术，发展一种碳离子束触发释放化疗药物的多功能稀土纳米材料，用于肿瘤淋巴结微转移的早期诊断和特异性放化疗一体化治疗。该体系用于肿瘤淋巴微转移多模式成像兼顾成像组织分辨率和绝对定量化，同时可以不受病灶深度限制，实现特点位点释放化疗药物，从而实现特异性的放、化疗同时治疗。目标是在极低的正常组织损伤情况下，通过正电子发射成像和磁共振成像提高肿瘤淋巴微转移的早期检出率，并推动碳离子治疗和特异性化疗结合进一步提高碳离子治疗的肿瘤控制率。

基于稀土元素的相似性和多功能性、高能碳离子束的高线性能量传递特点以及高效切断DN A双链的能力，利用纳米技术，发展一种碳离子束触发释放化疗药物的多功能稀土纳米材料， 用于肿瘤淋巴结微转移的早期诊断和特异性放化疗一体化治疗。该体系用于肿瘤淋巴微转移多 模式成像兼顾成像组织分辨率和绝对定量化，同时可以不受病灶深度限制，实现特点位点释放 化疗药物，从而实现特异性的放、化疗同时治疗。目标是在极低的正常组织损伤情况下，通过 正电子发射成像和磁共振成像提高肿瘤淋巴微转移的早期检出率，并推动碳离子治疗和特异性 化疗结合进一步提高碳离子治疗的肿瘤控制率。

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