MURU对子宫血液动力学和卵巢功能影响的研究

Adenomyosis is a highly incidence diseases in gynecology, due to various reasons, hysterectomy is still the main methods to treat this disease, especially in patients with severe conditions. Our preliminary studies indicate that major uterine wall resection and reconstruction of the uterus (MURU) would have a good therapeutic effect on adenomyosis. However, as a new surgical approach, the impact of MURU on uterine hemodynamic and ovarian function is still unclear, this project intends to analyze the uterine vascular resistance index (RI), pulsatility index (PI) as well as antral follicle count (AFC) and anti-Müllerian hormone (AMH) pre- and post MURU, in order to research the effects of MURU on uterine hemodynamic and ovarian function ,and for the further purpose of providing evidence for promoting the application of MURU in clinic.

子宫腺肌病是妇科高发疾病，我们的前期研究结果表明，肌壁大部切除-子宫重建术（major uterine wall resection and reconstruction of the uterus, MURU）对子宫腺肌病具有良好的治疗效果。但是，作为一种新的手术方式，MURU对子宫血液动力学和卵巢功能产生的影响尚不清楚，本项目拟通过经阴道彩超检测子宫血管阻力指数(resistance index,RI)、搏动指数(pulsatility index,PI)、窦卵泡计数（antral follicle count,AFC）以及测量血清抗苗勒激素(anti-mullerian homone,AMH)，研究MURU术前、术后子宫血液动力学和卵巢功能的变化，分析MURU对子宫血液动力学和卵巢功能造成的影响，并以同期子宫肌瘤切除患者进行对比，以期为MURU的推广应用提供循证依据。