"灰尘暴露组"毒性评价以及健康高风险化合物确定

Human spend most of their time (>70%) in indoor environment. Thus, inevitable exposure to indoor pollutants is of great concern for human health. Indoor dust is a sink for most indoor chemicals, and its ingestion is an important pathway for chemical uptake. Therefore, the chemical atlas from dust is an ideal environmental sample to investigate indoor exposure and associated risk. The proposal will conduct a literature survey on the occurrence and concentration levels of organic and inorganic compounds in indoor dust worldwide, establish an "indoor dust exposome" that contains both the types and concentrations of chemicals, and combine the EPA ToxCast database to analyze toxicity prioritization in different toxicological end points. The proposal will also use indoor dust extracts to treat human cells, using metabolomics and transcriptomics methods to find out the affected metabolites and metabolic pathways, and affected genes and expression pathways, and further combine Effect-Directed Analyze to confirm possible compounds that cause adverse effects. Overall, this project will establish an indoor dust exposome database, and will explore a novel risk assessment platform that combines indoor dust and omics technology, to provide data support for future indoor exposure research and risk assessment; the key causal components that affect health will be identified to provide guidance for indoor air quality control.

人类大部分时间（>70％）在室内度过，室内污染物暴露是影响人体健康的关键因素之一。室内灰尘是众多环境污染物的聚集地，而灰尘摄入是污染物暴露的重要途径之一，因此，室内灰尘是研究室内暴露与健康风险评估的重要环境相关性样品。该项目将对世界范围内室内灰尘中有机和无机化合物的发生和浓度水平进行文献调研，建立包含污染物种类与浓度的“灰尘暴露组”，并结合EPA ToxCast数据库，对不同毒性终点中化学物质的重要性优先排序。该项目将使用室内灰尘提取物处理人体细胞，通过代谢组学和转录组学等方法，寻找被影响的代谢物和代谢途径，找出表达被影响的基因和表达途径，进一步结合效应导向分析找出引起不良影响的可能化合物。该项目将建立室内灰尘暴露数据库，并将探索一个全新的室内灰尘和组学技术相结合的风险评估平台，为未来室内暴露研究和风险评估提供数据支持；将明确室内灰尘中影响健康的关键成分，为室内空气质量检测提供指导。

人类大部分时间（>70％）在室内度过，室内污染物暴露是影响人体健康的关键因素之一。室内灰尘是众多环境污染物的聚集地，而灰尘摄入是污染物暴露的重要途径之一，因此，室内灰尘是研究室内暴露与健康风险评估的重要环境相关性样品。该项目将对世界范围内室内灰尘中有机和无机化合物的发生和浓度水平进行文献调研，建立同时包含污染物种类与浓度的“灰尘暴露组”，并结合EPA ToxCast数据库，对不同毒性终点中化学物质的重要性进行优先排序。该项目使用室内灰尘提取物处理人体细胞模型，通过代谢组学和转录组学等方法，寻找被影响的代谢物和代谢途径，找出了表达被影响的重要基因和表达途径，进一步结合效应导向分析找出了引起不良影响的可能化合物。该项目建立了室内灰尘暴露数据库，探索了一个全新的室内灰尘和组学技术相结合的风险评估平台，为未来室内暴露研究和风险评估提供了可靠的数据支持；并将明确室内灰尘中影响健康的关键成分，为室内空气质量检测提供指导。

内容获取失败，请点击重试